MiRNA EXPRESSION ASSAYS

Cornelia Braicu; Beatriz M. Maia; Ioana Berindan-Neagoe; George A. Calin

doi:10.1007/978-1-4939-0727-4_4

MiRNA EXPRESSION ASSAYS

Cornelia Braicu
, Beatriz M. Maia
, Ioana Berindan-Neagoe
, George A. Calin

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs. Evaluation of miRNA expression profiles has come to play an important role in diverse physiological and pathological processes. In this chapter, we provide an overview of several of the most recently developed assays, methods, and technologies used to identify, characterize, and confirm miRNA expression in human pathologies. We also outline principal workflows for different preparations of biological samples, taking into account advantages and disadvantages of each approach. Furthermore, we discuss the diagnostic and therapeutic efficacy of miRNAs as well as their future roles in personalized medicine. This complete picture can help pathologists combine new methods and classical ones for diagnostic and therapeutic purposes.

Original language	English (US)
Title of host publication	Genomic Applications in Pathology
Publisher	Springer New York
Pages	45-70
Number of pages	26
ISBN (Electronic)	9781493907274
ISBN (Print)	9781493907267
DOIs	https://doi.org/10.1007/978-1-4939-0727-4_4
State	Published - Jan 1 2014

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

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10.1007/978-1-4939-0727-4_4

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abstract = "MicroRNAs (miRNAs) are small noncoding RNAs. Evaluation of miRNA expression profiles has come to play an important role in diverse physiological and pathological processes. In this chapter, we provide an overview of several of the most recently developed assays, methods, and technologies used to identify, characterize, and confirm miRNA expression in human pathologies. We also outline principal workflows for different preparations of biological samples, taking into account advantages and disadvantages of each approach. Furthermore, we discuss the diagnostic and therapeutic efficacy of miRNAs as well as their future roles in personalized medicine. This complete picture can help pathologists combine new methods and classical ones for diagnostic and therapeutic purposes.",

author = "Cornelia Braicu and Maia, \{Beatriz M.\} and Ioana Berindan-Neagoe and Calin, \{George A.\}",

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AU - Maia, Beatriz M.

AU - Berindan-Neagoe, Ioana

AU - Calin, George A.

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Y1 - 2014/1/1

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AB - MicroRNAs (miRNAs) are small noncoding RNAs. Evaluation of miRNA expression profiles has come to play an important role in diverse physiological and pathological processes. In this chapter, we provide an overview of several of the most recently developed assays, methods, and technologies used to identify, characterize, and confirm miRNA expression in human pathologies. We also outline principal workflows for different preparations of biological samples, taking into account advantages and disadvantages of each approach. Furthermore, we discuss the diagnostic and therapeutic efficacy of miRNAs as well as their future roles in personalized medicine. This complete picture can help pathologists combine new methods and classical ones for diagnostic and therapeutic purposes.

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BT - Genomic Applications in Pathology

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ER -

MiRNA EXPRESSION ASSAYS

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