miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer

Deepak Parashar; Anjali Geethadevi; Miriam Ragle Aure; Jyotsna Mishra; Jasmine George; Changliang Chen; Manoj K. Mishra; Andliena Tahiri; Wei Zhao; Bindu Nair; Yiling Lu; Lingegowda S. Mangala; Cristian Rodriguez-Aguayo; Gabriel Lopez-Berestein; Amadou K.S. Camara; Mingyu Liang; Janet S. Rader; Ramani Ramchandran; Ming You; Anil K. Sood; Vessela N. Kristensen; Gordon B. Mills; Sunila Pradeep; Pradeep Chaluvally-Raghavan

doi:10.1016/j.celrep.2019.11.085

miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer

Deepak Parashar, Anjali Geethadevi, Miriam Ragle Aure, Jyotsna Mishra, Jasmine George, Changliang Chen, Manoj K. Mishra, Andliena Tahiri, Wei Zhao, Bindu Nair, Yiling Lu, Lingegowda S. Mangala, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Amadou K.S. Camara, Mingyu Liang, Janet S. Rader, Ramani Ramchandran, Ming You, Anil K. SoodVessela N. Kristensen, Gordon B. Mills, Sunila Pradeep, Pradeep Chaluvally-Raghavan

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53 Scopus citations

Abstract

Parashar et al. demonstrate that the mature microRNA-551b-3p translocates to the nucleus for transcriptional activation of STAT3 gene. As a consequence, miR551b activates an autocrine signaling loop through the upregulation of oncostatin family genes, including oncostatin, and its receptors for the growth and metastasis of triple-negative breast cancer.

Original language	English (US)
Pages (from-to)	4389-4406.e10
Journal	Cell Reports
Volume	29
Issue number	13
DOIs	https://doi.org/10.1016/j.celrep.2019.11.085
State	Published - Dec 24 2019

Keywords

IPO8
OSMR
RNAi
STAT3
miR551b
miRNA-therapy
oncostatin

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

MD Anderson CCSG core facilities

Bioinformatics Shared Resource
Functional Proteomics Reverse Phase Protein Array Core

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10.1016/j.celrep.2019.11.085

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Parashar, D., Geethadevi, A., Aure, M. R., Mishra, J., George, J., Chen, C., Mishra, M. K., Tahiri, A., Zhao, W., Nair, B., Lu, Y., Mangala, L. S., Rodriguez-Aguayo, C., Lopez-Berestein, G., Camara, A. K. S., Liang, M., Rader, J. S., Ramchandran, R., You, M., ... Chaluvally-Raghavan, P. (2019). miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer. Cell Reports, 29(13), 4389-4406.e10. https://doi.org/10.1016/j.celrep.2019.11.085

Parashar, D, Geethadevi, A, Aure, MR, Mishra, J, George, J, Chen, C, Mishra, MK, Tahiri, A, Zhao, W, Nair, B, Lu, Y , Mangala, LS , Rodriguez-Aguayo, C , Lopez-Berestein, G, Camara, AKS, Liang, M, Rader, JS, Ramchandran, R, You, M, Sood, AK, Kristensen, VN, Mills, GB, Pradeep, S & Chaluvally-Raghavan, P 2019, 'miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer', Cell Reports, vol. 29, no. 13, pp. 4389-4406.e10. https://doi.org/10.1016/j.celrep.2019.11.085

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title = "miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer",

abstract = "Parashar et al. demonstrate that the mature microRNA-551b-3p translocates to the nucleus for transcriptional activation of STAT3 gene. As a consequence, miR551b activates an autocrine signaling loop through the upregulation of oncostatin family genes, including oncostatin, and its receptors for the growth and metastasis of triple-negative breast cancer.",

keywords = "IPO8, OSMR, RNAi, STAT3, miR551b, miRNA-therapy, oncostatin",

author = "Deepak Parashar and Anjali Geethadevi and Aure, {Miriam Ragle} and Jyotsna Mishra and Jasmine George and Changliang Chen and Mishra, {Manoj K.} and Andliena Tahiri and Wei Zhao and Bindu Nair and Yiling Lu and Mangala, {Lingegowda S.} and Cristian Rodriguez-Aguayo and Gabriel Lopez-Berestein and Camara, {Amadou K.S.} and Mingyu Liang and Rader, {Janet S.} and Ramani Ramchandran and Ming You and Sood, {Anil K.} and Kristensen, {Vessela N.} and Mills, {Gordon B.} and Sunila Pradeep and Pradeep Chaluvally-Raghavan",

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doi = "10.1016/j.celrep.2019.11.085",

language = "English (US)",

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T1 - miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer

AU - Parashar, Deepak

AU - Geethadevi, Anjali

AU - Aure, Miriam Ragle

AU - Mishra, Jyotsna

AU - George, Jasmine

AU - Chen, Changliang

AU - Mishra, Manoj K.

AU - Tahiri, Andliena

AU - Zhao, Wei

AU - Nair, Bindu

AU - Lu, Yiling

AU - Mangala, Lingegowda S.

AU - Rodriguez-Aguayo, Cristian

AU - Lopez-Berestein, Gabriel

AU - Camara, Amadou K.S.

AU - Liang, Mingyu

AU - Rader, Janet S.

AU - Ramchandran, Ramani

AU - You, Ming

AU - Sood, Anil K.

AU - Kristensen, Vessela N.

AU - Mills, Gordon B.

AU - Pradeep, Sunila

AU - Chaluvally-Raghavan, Pradeep

PY - 2019/12/24

Y1 - 2019/12/24

N2 - Parashar et al. demonstrate that the mature microRNA-551b-3p translocates to the nucleus for transcriptional activation of STAT3 gene. As a consequence, miR551b activates an autocrine signaling loop through the upregulation of oncostatin family genes, including oncostatin, and its receptors for the growth and metastasis of triple-negative breast cancer.

AB - Parashar et al. demonstrate that the mature microRNA-551b-3p translocates to the nucleus for transcriptional activation of STAT3 gene. As a consequence, miR551b activates an autocrine signaling loop through the upregulation of oncostatin family genes, including oncostatin, and its receptors for the growth and metastasis of triple-negative breast cancer.

KW - IPO8

KW - OSMR

KW - RNAi

KW - STAT3

KW - miR551b

KW - miRNA-therapy

KW - oncostatin

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SP - 4389-4406.e10

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miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

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