MK-801 inhibits the development of morphine tolerance at spinal sites

Howard B. Gutstein; Keith A. Trujillo

doi:10.1016/0006-8993(93)90597-G

MK-801 inhibits the development of morphine tolerance at spinal sites

Howard B. Gutstein
, Keith A. Trujillo

Anesthesiology & PeriOperative Medicine

Research output: Contribution to journal › Article › peer-review

94 Scopus citations

Abstract

The N-methyl-d-aspartate (NMDA) receptor antagonist MK-801 has been shown to attenuate tolerance development in rats. In this study, we show that MK-801 inhibits tolerance to the antinociceptive effects of morphine, as assessed by the tail-flick test, in spinalized rats. These results suggest that NMDA receptor antagonists inhibit opiate tolerance at spinal sites, and also provide strong evidence that the effects of MK-801 are not due to its ability to interfere with associative learning, but instead to inhibition of non-associative mechanisms of opiate tolerance.

Original language	English (US)
Pages (from-to)	332-334
Number of pages	3
Journal	Brain Research
Volume	626
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(93)90597-G
State	Published - Oct 29 1993

Keywords

Antinociception
MK-801
NMDA
Opiate tolerance
Spinal cord
Tail flick test

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(93)90597-G

Cite this

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title = "MK-801 inhibits the development of morphine tolerance at spinal sites",

abstract = "The N-methyl-d-aspartate (NMDA) receptor antagonist MK-801 has been shown to attenuate tolerance development in rats. In this study, we show that MK-801 inhibits tolerance to the antinociceptive effects of morphine, as assessed by the tail-flick test, in spinalized rats. These results suggest that NMDA receptor antagonists inhibit opiate tolerance at spinal sites, and also provide strong evidence that the effects of MK-801 are not due to its ability to interfere with associative learning, but instead to inhibition of non-associative mechanisms of opiate tolerance.",

keywords = "Antinociception, MK-801, NMDA, Opiate tolerance, Spinal cord, Tail flick test",

author = "Gutstein, \{Howard B.\} and Trujillo, \{Keith A.\}",

note = "Funding Information: We would like to thank Dr. Huda Akil for her generous advice, encouragement and financial support, and James Stewart for his excellent technical assistance. This work was supported by NIDA Grant DA02265, the Lucille Markey Charitable Fund, and a Department of Anesthesiology starter grant.",

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AU - Trujillo, Keith A.

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N2 - The N-methyl-d-aspartate (NMDA) receptor antagonist MK-801 has been shown to attenuate tolerance development in rats. In this study, we show that MK-801 inhibits tolerance to the antinociceptive effects of morphine, as assessed by the tail-flick test, in spinalized rats. These results suggest that NMDA receptor antagonists inhibit opiate tolerance at spinal sites, and also provide strong evidence that the effects of MK-801 are not due to its ability to interfere with associative learning, but instead to inhibition of non-associative mechanisms of opiate tolerance.

AB - The N-methyl-d-aspartate (NMDA) receptor antagonist MK-801 has been shown to attenuate tolerance development in rats. In this study, we show that MK-801 inhibits tolerance to the antinociceptive effects of morphine, as assessed by the tail-flick test, in spinalized rats. These results suggest that NMDA receptor antagonists inhibit opiate tolerance at spinal sites, and also provide strong evidence that the effects of MK-801 are not due to its ability to interfere with associative learning, but instead to inhibition of non-associative mechanisms of opiate tolerance.

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KW - MK-801

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KW - Opiate tolerance

KW - Spinal cord

KW - Tail flick test

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MK-801 inhibits the development of morphine tolerance at spinal sites

Abstract

Keywords

ASJC Scopus subject areas

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