Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: Characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy

Parmeswaran Diagaradjane; Anil Shetty; James C. Wang; Andrew M. Elliott; Jon Schwartz; Shujun Shentu; Hee C. Park; Amit Deorukhkar; R. Jason Stafford; Sang H. Cho; James W. Tunnell; John D. Hazle; Sunil Krishnan

doi:10.1021/nl080496z

Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: Characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy

Parmeswaran Diagaradjane, Anil Shetty, James C. Wang, Andrew M. Elliott, Jon Schwartz, Shujun Shentu, Hee C. Park, Amit Deorukhkar, R. Jason Stafford, Sang H. Cho, James W. Tunnell, John D. Hazle, Sunil Krishnan

Research output: Contribution to journal › Article › peer-review

206 Scopus citations

Abstract

We report noninvasive modulation of in vivo tumor radiation response using gold nanoshells. Mild-temperature hyperthermia generated by near-infrared illumination of gold nanoshell-laden tumors, noninvasively quantified by magnetic resonance temperature imaging, causes an early increase in tumor perfusion that reduces the hypoxic fraction of tumors. A subsequent radiation dose induces vascular disruption with extensive tumor necrosis. Gold nanoshells sequestered in the perivascular space mediate these two tumor vasculature-focused effects to improve radiation response of tumors. This novel integrated antihypoxic and localized vascular disrupting therapy can potentially be combined with other conventional antitumor therapies.

Original language	English (US)
Pages (from-to)	1492-1500
Number of pages	9
Journal	Nano Letters
Volume	8
Issue number	5
DOIs	https://doi.org/10.1021/nl080496z
State	Published - May 2008

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

MD Anderson CCSG core facilities

High Resolution Electron Microscopy Facility
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10.1021/nl080496z

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Diagaradjane, P., Shetty, A., Wang, J. C., Elliott, A. M., Schwartz, J., Shentu, S., Park, H. C., Deorukhkar, A., Stafford, R. J., Cho, S. H., Tunnell, J. W., Hazle, J. D., & Krishnan, S. (2008). Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: Characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy. Nano Letters, 8(5), 1492-1500. https://doi.org/10.1021/nl080496z

Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: Characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy. / Diagaradjane, Parmeswaran; Shetty, Anil; Wang, James C. et al.
In: Nano Letters, Vol. 8, No. 5, 05.2008, p. 1492-1500.

Research output: Contribution to journal › Article › peer-review

Diagaradjane, P, Shetty, A, Wang, JC, Elliott, AM, Schwartz, J, Shentu, S, Park, HC, Deorukhkar, A, Stafford, RJ , Cho, SH, Tunnell, JW, Hazle, JD & Krishnan, S 2008, 'Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: Characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy', Nano Letters, vol. 8, no. 5, pp. 1492-1500. https://doi.org/10.1021/nl080496z

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abstract = "We report noninvasive modulation of in vivo tumor radiation response using gold nanoshells. Mild-temperature hyperthermia generated by near-infrared illumination of gold nanoshell-laden tumors, noninvasively quantified by magnetic resonance temperature imaging, causes an early increase in tumor perfusion that reduces the hypoxic fraction of tumors. A subsequent radiation dose induces vascular disruption with extensive tumor necrosis. Gold nanoshells sequestered in the perivascular space mediate these two tumor vasculature-focused effects to improve radiation response of tumors. This novel integrated antihypoxic and localized vascular disrupting therapy can potentially be combined with other conventional antitumor therapies.",

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AU - Hazle, John D.

AU - Krishnan, Sunil

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Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: Characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy

Abstract

ASJC Scopus subject areas

MD Anderson CCSG core facilities

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