TY - JOUR
T1 - Molecular Biology of Oral Cavity Squamous Cell Carcinoma
AU - Kupferman, Michael E.
AU - Myers, Jeffrey N.
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2006/4
Y1 - 2006/4
N2 - Significant advances have been made in understanding the mechanisms that contribute to carcinogenesis in OCSCC. This progress has led to the development of therapeutic strategies that target dysregulated processes in the tumor microenvironment (Fig. 11) [72]. The introduction of angiogenesis inhibitors, growth factor receptor tyrosine kinase inhibitors, and cell cycle regulators into clinical trials for the management of OCSCC has resulted from the great strides made in the understanding of tumor biology. It is important for those caring for patients who have OCSCC to have a firm background in tumor biology, because many future therapies will be based on this complex panorama of cellular physiology.
AB - Significant advances have been made in understanding the mechanisms that contribute to carcinogenesis in OCSCC. This progress has led to the development of therapeutic strategies that target dysregulated processes in the tumor microenvironment (Fig. 11) [72]. The introduction of angiogenesis inhibitors, growth factor receptor tyrosine kinase inhibitors, and cell cycle regulators into clinical trials for the management of OCSCC has resulted from the great strides made in the understanding of tumor biology. It is important for those caring for patients who have OCSCC to have a firm background in tumor biology, because many future therapies will be based on this complex panorama of cellular physiology.
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U2 - 10.1016/j.otc.2005.11.003
DO - 10.1016/j.otc.2005.11.003
M3 - Review article
C2 - 16580909
AN - SCOPUS:33645851349
SN - 0030-6665
VL - 39
SP - 229
EP - 247
JO - Otolaryngologic Clinics of North America
JF - Otolaryngologic Clinics of North America
IS - 2
ER -