Molecular genetic studies on ganglioglioma

Xiao lu Yin, Ho Keung Ng

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

OBJECTIVE: To study the genetic alterations of ganglioglioma through the entire genome, and to investigate the pathogenesis of this neoplasm. METHODS: Comparative genomic hybridization was used to provide an overview of genetic abnormalities in gangliogliomas. RESULTS: Five cases of gangliogliomas, including 3 males and 2 females, were studied genetically. Loss of genetic materials on the short arm of chromosome 9(9p) was a common genetic alteration found in 3 of 5 cases. Overrepresentation of chromosome 7 was another recurrent chromosomal imbalance, which was further confirmed by fluorescence in situ hybridization. Immunohistochemical analysis was performed on epidermal growth factor receptor (EGFR), which was located on 7p11-p13. All five cases revealed no abnormal expression of EGFR. On the other hand, genetic imbalances were also involved in multiple chromosomes including 2q33-q34, 8q12-q22, 14q21-qter, 15q26-qter and Y. CONCLUSION: Loss of genetic materials on chromosome 9p and gain on chromosome 7 may be associated with the pathogenesis of this neoplasm.

Original languageEnglish (US)
Pages (from-to)147-149
Number of pages3
JournalZhonghua bing li xue za zhi Chinese journal of pathology
Volume34
Issue number3
StatePublished - Mar 2005

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Ganglioglioma
Molecular Biology
Chromosomes, Human, Pair 7
Epidermal Growth Factor Receptor
Chromosomes
Chromosomes, Human, Pair 9
Comparative Genomic Hybridization
Fluorescence In Situ Hybridization
Genes
Neoplasms
Genome

ASJC Scopus subject areas

  • Medicine(all)

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Molecular genetic studies on ganglioglioma. / Yin, Xiao lu; Ng, Ho Keung.

In: Zhonghua bing li xue za zhi Chinese journal of pathology, Vol. 34, No. 3, 03.2005, p. 147-149.

Research output: Contribution to journalArticle

Yin, Xiao lu ; Ng, Ho Keung. / Molecular genetic studies on ganglioglioma. In: Zhonghua bing li xue za zhi Chinese journal of pathology. 2005 ; Vol. 34, No. 3. pp. 147-149.
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