Molecular mechanisms of long noncoding RNAs-mediated cancer metastasis

Yajuan Li, Sergey D. Egranov, Liuqing Yang, Chunru Lin

Research output: Contribution to journalReview articlepeer-review

70 Scopus citations

Abstract

Cancer metastasis is a multistep process that requires cancer cells to leave the primary site, survive in the blood stream, and finally colonize at a distant organ. It is the major cause of cancer morbidity and mortality. The organ-specific colonization requires close interaction and communication between cancer cells and host organs. Noncoding RNAs represent the majority of the transcriptome, with long noncoding RNAs (lncRNAs) making up a significant proportion. It has been suggested that lncRNAs play a key role in all stages of tumorigenesis and metastasis. This review will provide an overview of how lncRNAs are involved in cancer cell colonization in specific organ sites and the underlying mechanisms as well as therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)200-207
Number of pages8
JournalGenes Chromosomes and Cancer
Volume58
Issue number4
DOIs
StatePublished - Apr 2019

Keywords

  • angiogenesis
  • cancer
  • cell invasion
  • colonize
  • hypoxia
  • long noncoding RNAs
  • metastasis
  • oligonucleotide therapeutics
  • organ-specific
  • small molecule inhibitor
  • tumor microenvironment

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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