Molecular pharmacology of the haloethyl nitrosoureas: Formation of 6-hydroxyethylguanine in DNA treated with BCNU (N,N1-bis[2-chloroethyl]-N-nitrosourea)

William P. Tong; Marion C. Kirk; David B. Ludlum

doi:10.1016/S0006-291X(81)80103-9

Molecular pharmacology of the haloethyl nitrosoureas: Formation of 6-hydroxyethylguanine in DNA treated with BCNU (N,N¹-bis[2-chloroethyl]-N-nitrosourea)

William P. Tong
, Marion C. Kirk
, David B. Ludlum

Cancer Systems Imaging

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The substituted base, 6-(β-hydroxyethyl)guanine, has been identified in DNA which has been treated with the antitumor agent, N,N¹-bis(2-chloroethyl)-N-nitrosourea (BCNU). This finding provides support for the suggestion that interstrand crosslinks may involve substitution at this position. The presence of 6-hydroxyethylguanine in DNA could also explain the carcinogenic potential of the haloethyl nitrosoureas since this DNA modification is considered mutagenic.

Original language	English (US)
Pages (from-to)	351-357
Number of pages	7
Journal	Biochemical and biophysical research communications
Volume	100
Issue number	1
DOIs	https://doi.org/10.1016/S0006-291X(81)80103-9
State	Published - May 15 1981

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/S0006-291X(81)80103-9

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Molecular pharmacology of the haloethyl nitrosoureas: Formation of 6-hydroxyethylguanine in DNA treated with BCNU (N,N¹-bis[2-chloroethyl]-N-nitrosourea). / Tong, William P.; Kirk, Marion C.; Ludlum, David B.
In: Biochemical and biophysical research communications, Vol. 100, No. 1, 15.05.1981, p. 351-357.

Research output: Contribution to journal › Article › peer-review

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abstract = "The substituted base, 6-(β-hydroxyethyl)guanine, has been identified in DNA which has been treated with the antitumor agent, N,N1-bis(2-chloroethyl)-N-nitrosourea (BCNU). This finding provides support for the suggestion that interstrand crosslinks may involve substitution at this position. The presence of 6-hydroxyethylguanine in DNA could also explain the carcinogenic potential of the haloethyl nitrosoureas since this DNA modification is considered mutagenic.",

author = "Tong, \{William P.\} and Kirk, \{Marion C.\} and Ludlum, \{David B.\}",

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AB - The substituted base, 6-(β-hydroxyethyl)guanine, has been identified in DNA which has been treated with the antitumor agent, N,N1-bis(2-chloroethyl)-N-nitrosourea (BCNU). This finding provides support for the suggestion that interstrand crosslinks may involve substitution at this position. The presence of 6-hydroxyethylguanine in DNA could also explain the carcinogenic potential of the haloethyl nitrosoureas since this DNA modification is considered mutagenic.

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Molecular pharmacology of the haloethyl nitrosoureas: Formation of 6-hydroxyethylguanine in DNA treated with BCNU (N,N¹-bis[2-chloroethyl]-N-nitrosourea)

Abstract

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