TY - JOUR
T1 - Molecular photoacoustic imaging with ultrasmall gold nanoparticles
AU - Han, Sangheon
AU - Bouchard, Richard
AU - Sokolov, Konstantin V.
N1 - Funding Information:
NIH (R01EB008101); CPRIT (RP170314). The authors would like to acknowledge Ian S. Kinstlinger and Dr. Jordan Miller for assistance with design and printing of the phantom mold and CCSG grant NIH (P30CA016672) and High Resolution Electron Microscopy Facility for the use of transmission electron microscopy.
Publisher Copyright:
© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.
PY - 2019/7
Y1 - 2019/7
N2 - Gold nanoparticles (AuNPs) below 10 nm in size can undergo renal clearance, which could facilitate their clinical translation. However, due to non-linear, direct relationship between their absorption and size, use of such “ultra-small” AuNPs as contrast agents for photoacoustic imaging (PAI) is challenging. This problem is complicated by the tendency of absorption for ultra-small AuNPs to be below the NIR range, which is optimal for in vivo imaging. Herein, we present 5-nm molecularly activated plasmonic nanosensors (MAPS) that produce a strong photoacoustic signal in labeled cancer cells in the NIR, demonstrating the feasibility of sensitive PAI with ultra-small AuNPs.
AB - Gold nanoparticles (AuNPs) below 10 nm in size can undergo renal clearance, which could facilitate their clinical translation. However, due to non-linear, direct relationship between their absorption and size, use of such “ultra-small” AuNPs as contrast agents for photoacoustic imaging (PAI) is challenging. This problem is complicated by the tendency of absorption for ultra-small AuNPs to be below the NIR range, which is optimal for in vivo imaging. Herein, we present 5-nm molecularly activated plasmonic nanosensors (MAPS) that produce a strong photoacoustic signal in labeled cancer cells in the NIR, demonstrating the feasibility of sensitive PAI with ultra-small AuNPs.
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U2 - 10.1364/BOE.10.003472
DO - 10.1364/BOE.10.003472
M3 - Article
C2 - 31360601
AN - SCOPUS:85070779183
SN - 2156-7085
VL - 10
SP - 3472
EP - 3483
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 7
ER -