TY - JOUR
T1 - Monitoring sputum culture in resected esophageal cancer patients with preoperative treatment
AU - Kosumi, K.
AU - Baba, Y.
AU - Yamashita, K.
AU - Ishimoto, T.
AU - Nakamura, K.
AU - Ohuchi, M.
AU - Kiyozumi, Y.
AU - Izumi, D.
AU - Tokunaga, R.
AU - Harada, K.
AU - Shigaki, H.
AU - Kurashige, J.
AU - Iwatsuki, M.
AU - Sakamoto, Y.
AU - Yoshida, N.
AU - Watanabe, M.
AU - Baba, Hideo
N1 - Publisher Copyright:
© The Authors 2017. Published by Oxford University Press on behalf of International Society for Diseases of the Esophagus. All rights reserved.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Pneumonia is a major cause of postesophagectomy mortality and worsens the long-term survival in resected esophageal cancer patients. Moreover, preoperative treatments such as chemotherapy or chemoradiotherapy (which have recently been applied worldwide) might affect the bacterial flora of the sputum. To investigate the association among preoperative treatments, the bacterial flora of sputum, and the clinical and pathological features in resected esophageal cancer patients, this study newly investigates the effect of preoperative treatments on the bacterial flora of sputum.We investigated the association among preoperative treatments, the bacterial flora of sputum, and clinical and pathological features in 163 resected esophageal cancer patients within a single institution. Pathogenic bacteria such as Candida (14.1%), Staphylococcus aureus (6.7%), Enterobacter cloacae (6.1%), Haemophilus parainfluenzae (4.9%), Klebisiella pneumoniae (3.7%), Methicillin-resistant Staphylococcus aureus (MRSA) (3.7%), Pseudomonas aeruginosa (2.5%), Escherichia coli (1.8%), Streptococcus pneumoniae (1.8%), and Haemophilus influenzae (1.2%) were found in the sputum. The pathogen detection rate in the present study was 34.3% (56/163). In patients with preoperative chemotherapy and chemoradiotherapy, the indigenous Neisseria and Streptococcus species were significantly decreased (P = 0.04 and P = 0.04). However, the detection rates of pathogenic bacteria were not associated with preoperative treatments (all P > 0.07). There was not a significant difference of hospital stay between the sputum-monitored patients and unmonitored patients (35.5 vs. 49.9 days; P = 0.08). Patients undergoing preoperative treatments exhibited a significant decrease of indigenous bacteria, indicating that the treatment altered the bacterial flora of their sputum. This finding needs to be confirmed in largescale independent studies or well-designed multicenter studies.
AB - Pneumonia is a major cause of postesophagectomy mortality and worsens the long-term survival in resected esophageal cancer patients. Moreover, preoperative treatments such as chemotherapy or chemoradiotherapy (which have recently been applied worldwide) might affect the bacterial flora of the sputum. To investigate the association among preoperative treatments, the bacterial flora of sputum, and the clinical and pathological features in resected esophageal cancer patients, this study newly investigates the effect of preoperative treatments on the bacterial flora of sputum.We investigated the association among preoperative treatments, the bacterial flora of sputum, and clinical and pathological features in 163 resected esophageal cancer patients within a single institution. Pathogenic bacteria such as Candida (14.1%), Staphylococcus aureus (6.7%), Enterobacter cloacae (6.1%), Haemophilus parainfluenzae (4.9%), Klebisiella pneumoniae (3.7%), Methicillin-resistant Staphylococcus aureus (MRSA) (3.7%), Pseudomonas aeruginosa (2.5%), Escherichia coli (1.8%), Streptococcus pneumoniae (1.8%), and Haemophilus influenzae (1.2%) were found in the sputum. The pathogen detection rate in the present study was 34.3% (56/163). In patients with preoperative chemotherapy and chemoradiotherapy, the indigenous Neisseria and Streptococcus species were significantly decreased (P = 0.04 and P = 0.04). However, the detection rates of pathogenic bacteria were not associated with preoperative treatments (all P > 0.07). There was not a significant difference of hospital stay between the sputum-monitored patients and unmonitored patients (35.5 vs. 49.9 days; P = 0.08). Patients undergoing preoperative treatments exhibited a significant decrease of indigenous bacteria, indicating that the treatment altered the bacterial flora of their sputum. This finding needs to be confirmed in largescale independent studies or well-designed multicenter studies.
KW - Complication
KW - Esophageal cancer
KW - Esophagectomy
KW - Pneumonia
KW - Preoperative treatment
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U2 - 10.1093/dote/dox092
DO - 10.1093/dote/dox092
M3 - Article
C2 - 28881886
AN - SCOPUS:85039728915
SN - 1120-8694
VL - 30
JO - Diseases of the Esophagus
JF - Diseases of the Esophagus
IS - 12
M1 - dox092
ER -