Monocyte function in familial Mediterranean fever

M. Bar-Eli, R. Gallily, M. Levy, M. Eliakim

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Monocytes derived from the peripheral blood of patients with familial Mediterranean fever (FMF) demonstrated a consistently lower phagocytic capacity (38-44%) for 125I-labelled Shigella flexneri when compared to monocytes from healthy subjects. Phagocytosis of both viable and killed Staphylococcus albus was similar in patients and controls. However, FMF monocytes had a two- to eight-fold depressed bactericidal capacity against S. albus in comparison to normal monocytes. Acid phosphatase and β-glucuronidase monocyte activities were similar in patients and controls. It is suggested that the defects in monocyte function may be of importance in the pathogenesis of FMF. Colchicine had no effect on any of the indices studied.

Original languageEnglish (US)
Pages (from-to)265-270
Number of pages6
JournalAmerican Journal of the Medical Sciences
Volume274
Issue number3
DOIs
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine

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