TY - JOUR
T1 - Monocyte subpopulations in angiogenesis
AU - Dalton, Heather J.
AU - Armaiz-Pena, Guillermo N.
AU - Gonzalez-Villasana, Vianey
AU - Lopez-Berestein, Gabriel
AU - Bar-Eli, Menashe
AU - Sood, Anil K.
PY - 2014/3/1
Y1 - 2014/3/1
N2 - Growing understanding of the role of the tumor microenvironment in angiogenesis has brought monocytederived cells into focus. Monocyte subpopulations are an increasingly attractive therapeutic target in many pathologic states, including cancer. Before monocyte-directed therapies can be fully harnessed for clinical use, understanding of monocyte-driven angiogenesis in tissue development and homeostasis, as well as malignancy, is required. Here, we provide an overview of the mechanisms by which monocytic subpopulations contribute to angiogenesis in tissue and tumor development, highlight gaps in our existing knowledge, and discuss opportunities to exploit these cells for clinical benefit.
AB - Growing understanding of the role of the tumor microenvironment in angiogenesis has brought monocytederived cells into focus. Monocyte subpopulations are an increasingly attractive therapeutic target in many pathologic states, including cancer. Before monocyte-directed therapies can be fully harnessed for clinical use, understanding of monocyte-driven angiogenesis in tissue development and homeostasis, as well as malignancy, is required. Here, we provide an overview of the mechanisms by which monocytic subpopulations contribute to angiogenesis in tissue and tumor development, highlight gaps in our existing knowledge, and discuss opportunities to exploit these cells for clinical benefit.
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U2 - 10.1158/0008-5472.CAN-13-2825
DO - 10.1158/0008-5472.CAN-13-2825
M3 - Review article
C2 - 24556724
AN - SCOPUS:84896525257
SN - 0008-5472
VL - 74
SP - 1287
EP - 1293
JO - Cancer Research
JF - Cancer Research
IS - 5
ER -