MR imaging of liver fibrosis: Current state of the art

Silvana C. Faria, Karthik Ganesan, Irene Mwangi, Masoud Shiehmorteza, Barbara Viamonte, Sameer Mazhar, Michael Peterson, Yuko Kono, Cynthia Santillan, Giovanna Casola, Claude B. Sirlin

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

Chronic liver disease is a major public health problem worldwide. Liver fibrosis, a common feature of almost all causes of chronic liver disease, involves the accumulation of collagen, proteoglycans, and other macromolecules within the extracellular matrix. Fibrosis tends to progress, leading to hepatic dysfunction, portal hypertension, and ultimately cirrhosis. Liver biopsy, the standard of reference for diagnosing liver fibrosis, is invasive, costly, and subject to complications and sampling variability. These limitations make it unsuitable for diagnosis and longitudinal monitoring in the general population. Thus, development of a noninvasive, accurate, and reproducible test for diagnosis and monitoring of liver fibrosis would be of great value. Conventional cross-sectional imaging techniques have limited capability to demonstrate liver fibrosis. In clinical practice, imaging studies are usually reserved for evaluation of the presence of portal hypertension or hepatocellular carcinoma in cases that have progressed to cirrhosis. In response to the rising prevalence of chronic liver diseases in Western nations, a number of imagingbased methods including ultrasonography-based transient elastography, computed tomography-based texture analysis, and diverse magnetic resonance (MR) imaging-based techniques have been proposed for noninvasive diagnosis and grading of hepatic fibrosis across its entire spectrum of severity. State-of-the-art MR imaging-based techniques in current practice and in development for noninvasive assessment of liver fibrosis include conventional contrast material-enhanced MR imaging, double contrast-enhanced MR imaging, MR elastography, diffusionweighted imaging, and MR perfusion imaging.

Original languageEnglish (US)
Pages (from-to)1615-1635
Number of pages21
JournalRadiographics
Volume29
Issue number6
DOIs
StatePublished - Oct 1 2009

Fingerprint

Liver Cirrhosis
Magnetic Resonance Imaging
Fibrosis
Elasticity Imaging Techniques
Liver Diseases
Chronic Disease
Portal Hypertension
Liver
Magnetic Resonance Angiography
Proteoglycans
Contrast Media
Extracellular Matrix
Hepatocellular Carcinoma
Ultrasonography
Collagen
Public Health
Tomography
Biopsy
Population

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Faria, S. C., Ganesan, K., Mwangi, I., Shiehmorteza, M., Viamonte, B., Mazhar, S., ... Sirlin, C. B. (2009). MR imaging of liver fibrosis: Current state of the art. Radiographics, 29(6), 1615-1635. https://doi.org/10.1148/rg.296095512

MR imaging of liver fibrosis : Current state of the art. / Faria, Silvana C.; Ganesan, Karthik; Mwangi, Irene; Shiehmorteza, Masoud; Viamonte, Barbara; Mazhar, Sameer; Peterson, Michael; Kono, Yuko; Santillan, Cynthia; Casola, Giovanna; Sirlin, Claude B.

In: Radiographics, Vol. 29, No. 6, 01.10.2009, p. 1615-1635.

Research output: Contribution to journalArticle

Faria, SC, Ganesan, K, Mwangi, I, Shiehmorteza, M, Viamonte, B, Mazhar, S, Peterson, M, Kono, Y, Santillan, C, Casola, G & Sirlin, CB 2009, 'MR imaging of liver fibrosis: Current state of the art', Radiographics, vol. 29, no. 6, pp. 1615-1635. https://doi.org/10.1148/rg.296095512
Faria SC, Ganesan K, Mwangi I, Shiehmorteza M, Viamonte B, Mazhar S et al. MR imaging of liver fibrosis: Current state of the art. Radiographics. 2009 Oct 1;29(6):1615-1635. https://doi.org/10.1148/rg.296095512
Faria, Silvana C. ; Ganesan, Karthik ; Mwangi, Irene ; Shiehmorteza, Masoud ; Viamonte, Barbara ; Mazhar, Sameer ; Peterson, Michael ; Kono, Yuko ; Santillan, Cynthia ; Casola, Giovanna ; Sirlin, Claude B. / MR imaging of liver fibrosis : Current state of the art. In: Radiographics. 2009 ; Vol. 29, No. 6. pp. 1615-1635.
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