MRI guided focused ultrasound surgery for the treatment of breast cancer

J. W. Jenne, R. Rastert, I. Simiantonakis, J. Debus, Peter Huber

Research output: Contribution to journalConference article

4 Citations (Scopus)

Abstract

HIFU is an effective tool to generate precise localized tissue heating and subsequent tissue necroses deep in the body. Especially in combination with MRI target definition, detection of the heated area and the detection of morphological tissue changes are possible. After previous animal trials we show in the present study the transfer of this method to the clinical application. We have treated human breast cancer with HIFU under MRI guidance. For this purpose, a clinical treatment unit was developed and built up. A prospective clinical phase I study was started involving patients with biopsy proven invasive breast cancer. MRI-guided focused ultrasound therapy was applied before conventional breast surgery. On MR-images breast tumor delineation, tumor segmentation and HIFU treatment planning was possible. During ultrasound therapy, detection of the thermal focus and comparison with the planned focus position allowed a quasi on-line therapy control. Immediately after ultrasound therapy affected areas could be distinguished after intravenous application of MRI contrast agent as non-perfused area. Thus we could demonstrate that breast cancer in a human patient can be treated non-invasively in a single therapy session with HIFU under MRI guidance.

Original languageEnglish (US)
Pages (from-to)1377-1380
Number of pages4
JournalProceedings of the IEEE Ultrasonics Symposium
Volume2
StatePublished - Dec 1 2001
Event2001 Ultrasonics Symposium - Atlanta, GA, United States
Duration: Oct 6 2001Oct 10 2001

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surgery
breast
therapy
cancer
tumors
delineation
necrosis
planning
animals
heating

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

MRI guided focused ultrasound surgery for the treatment of breast cancer. / Jenne, J. W.; Rastert, R.; Simiantonakis, I.; Debus, J.; Huber, Peter.

In: Proceedings of the IEEE Ultrasonics Symposium, Vol. 2, 01.12.2001, p. 1377-1380.

Research output: Contribution to journalConference article

Jenne, J. W. ; Rastert, R. ; Simiantonakis, I. ; Debus, J. ; Huber, Peter. / MRI guided focused ultrasound surgery for the treatment of breast cancer. In: Proceedings of the IEEE Ultrasonics Symposium. 2001 ; Vol. 2. pp. 1377-1380.
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