MSCs in solid tumors and hematological malignancies: From basic biology to therapeutic applications

Rodrigo Jacamo; Erika Spaeth; Venkata Battula; Frank Marini; Michael Andreeff

doi:10.1007/978-1-4614-5711-4_12

MSCs in solid tumors and hematological malignancies: From basic biology to therapeutic applications

Rodrigo Jacamo, Erika Spaeth, Venkata Battula, Frank Marini, Michael Andreeff

Leukemia

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Compelling experimental evidence has recently unveiled that the tumor microenvironment plays a crucial role in tumor progression. Importantly, bone marrow-derived mesenchymal stromal cells interact with tumor cells, and these interactions trigger a series of signaling responses that ultimately favor tumor progression and survival. In this chapter, we will describe how the stroma can influence tumor fate and also how we can utilize these stromal cells to deliver antitumoral therapeutic agents based on their innate tropism for tumors and injury sites.

Original language	English (US)
Title of host publication	Mesenchymal Stromal Cells
Subtitle of host publication	Biology and Clinical Applications
Publisher	Springer New York
Pages	209-235
Number of pages	27
ISBN (Electronic)	9781461457114
ISBN (Print)	9781461457107
DOIs	https://doi.org/10.1007/978-1-4614-5711-4_12
State	Published - Jan 1 2013

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/978-1-4614-5711-4_12

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MSCs in solid tumors and hematological malignancies: From basic biology to therapeutic applications

Abstract

ASJC Scopus subject areas

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