Skip to main navigation Skip to search Skip to main content

MSCs in Solid Tumors and Hematological Malignancies: From Basic Biology to Therapeutic Applications

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Compelling experimental evidence has recently unveiled that the tumor microenvironment plays a crucial role in tumor progression. Importantly, bone ­marrow-derived mesenchymal stromal cells interact with tumor cells, and these interactions trigger a series of signaling responses that ultimately favor tumor progression and survival. In this chapter, we will describe how the stroma can influence tumor fate and also how we can utilize these stromal cells to deliver antitumoral therapeutic agents based on their innate tropism for tumors and injury sites.

Original languageEnglish (US)
Title of host publicationStem Cell Biology and Regenerative Medicine
PublisherSpringer Nature
Pages209-235
Number of pages27
DOIs
StatePublished - 2013

Publication series

NameStem Cell Biology and Regenerative Medicine
VolumePart F4869
ISSN (Print)2196-8985
ISSN (Electronic)2196-8993

Keywords

  • Acute Myeloid Leukemia
  • Bone Marrow Microenvironment
  • Innate Tropism
  • Malignant Hematopoietic Cell
  • Suicide Gene Therapy

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine

Fingerprint

Dive into the research topics of 'MSCs in Solid Tumors and Hematological Malignancies: From Basic Biology to Therapeutic Applications'. Together they form a unique fingerprint.

Cite this