Abstract
Cancer is a complex disease and a leading cause of death worldwide. Immunity is critical for cancer control. Cancer cells exhibit high mutational rates and therefore altered self or neo-antigens, eliciting an immune response to promote tumor eradication. Failure to mount a proper immune response leads to cancer progression. mTOR signaling controls cellular metabolism, immune cell differentiation, and effector function. Deregulated mTOR signaling in cancer cells modulates the tumor microenvironment, thereby affecting tumor immunity and possibly promoting carcinogenesis.
Original language | English (US) |
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Article number | 578 |
Journal | Frontiers in immunology |
Volume | 9 |
Issue number | MAR |
DOIs | |
State | Published - Mar 27 2018 |
Keywords
- Immunity
- Immunotherapy
- Metabolism
- Rapamycin
- Signaling
- Tumorigenesis
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology