Multi-Modal Miniature Microscope (4M Device): Novel methodology for multimodality tissue imaging in vivo

Junwon Lee, Jeremy D. Rogers, Dawn Nida, Jesse S. Aaron, Konstantin Sokolov, Rebecca R. Richards-Kortum, Michael R. Descour

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations

Abstract

We are developing a multi-modal miniature microscope (4M device) for imaging morphology and cytochemistry in vivo and providing better delineation of tumors. The 4M device is designed to be a complete microscope on a chip, including optical, micro-mechanical, and electronic components. It has advantages such as compact size and capability for microscopic-scale imaging. This paper presents the recent imaging experiment of 4M device including trans-illumination imaging, TIR illumination imaging and fluorescent imaging. We built a multi-modal imaging test-bed to demonstrate multi-modality of 4M device. In this paper, we present imaging experiment results by implementing various imaging modality with cervical cancer cells. In order to enhance image contrast, some imaging modality uses cells attached with contrast agency such as silver nano-particles. Imaging results indicate that the 4M prototype can resolve cellular detail necessary for detection of precancer.

Original languageEnglish (US)
Pages (from-to)168-176
Number of pages9
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume4962
DOIs
StatePublished - 2003
Externally publishedYes
EventManipulation and Analysis of Biomolecules, Cells , and Tissues - San Jose, CA, United States
Duration: Jan 28 2003Jan 29 2003

Keywords

  • Fluorescence imaging
  • Multi-modal miniature microscope
  • Nano-particles
  • TIR reflectance imaging
  • Transmission imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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