Abstract
We are developing a multi-modal miniature microscope (4M device) for imaging morphology and cytochemistry in vivo and providing better delineation of tumors. The 4M device is designed to be a complete microscope on a chip, including optical, micro-mechanical, and electronic components. It has advantages such as compact size and capability for microscopic-scale imaging. This paper presents the recent imaging experiment of 4M device including trans-illumination imaging, TIR illumination imaging and fluorescent imaging. We built a multi-modal imaging test-bed to demonstrate multi-modality of 4M device. In this paper, we present imaging experiment results by implementing various imaging modality with cervical cancer cells. In order to enhance image contrast, some imaging modality uses cells attached with contrast agency such as silver nano-particles. Imaging results indicate that the 4M prototype can resolve cellular detail necessary for detection of precancer.
Original language | English (US) |
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Pages (from-to) | 168-176 |
Number of pages | 9 |
Journal | Proceedings of SPIE - The International Society for Optical Engineering |
Volume | 4962 |
DOIs | |
State | Published - 2003 |
Externally published | Yes |
Event | Manipulation and Analysis of Biomolecules, Cells , and Tissues - San Jose, CA, United States Duration: Jan 28 2003 → Jan 29 2003 |
Keywords
- Fluorescence imaging
- Multi-modal miniature microscope
- Nano-particles
- TIR reflectance imaging
- Transmission imaging
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
- Computer Science Applications
- Applied Mathematics
- Electrical and Electronic Engineering