TY - JOUR
T1 - Multi-stimuli responsive Cu2S nanocrystals as trimodal imaging and synergistic chemo-photothermal therapy agents
AU - Poulose, Aby Cheruvathoor
AU - Veeranarayanan, Srivani
AU - Mohamed, M. Sheikh
AU - Nagaoka, Yutaka
AU - Romero Aburto, Rebeca
AU - Mitcham, Trevor
AU - Ajayan, Pulickel M.
AU - Bouchard, Richard R.
AU - Sakamoto, Yasushi
AU - Yoshida, Yasuhiko
AU - Maekawa, Toru
AU - Sakthi Kumar, D.
N1 - Publisher Copyright:
© The Royal Society of Chemistry.
PY - 2015/5/14
Y1 - 2015/5/14
N2 - A size and shape tuned, multifunctional metal chalcogenide, Cu2S-based nanotheranostic agent is developed for trimodal imaging and multimodal therapeutics against brain cancer cells. This theranostic agent was highly efficient in optical, photoacoustic and X-ray contrast imaging systems. The folate targeted NIR-responsive photothermal ablation in synergism with the chemotherapeutic action of doxorubicin proved to be a rapid precision guided cancer-killing module. The multi-stimuli, i.e., pH-, thermo- and photo-responsive drug release behavior of the nanoconjugates opens up a wider corridor for on-demand triggered drug administration. The simple synthesis protocol, combined with the multitudes of interesting features packed into a single nanoformulation, clearly demonstrates the competing role of this Cu2S nanosystem in future cancer treatment strategies.
AB - A size and shape tuned, multifunctional metal chalcogenide, Cu2S-based nanotheranostic agent is developed for trimodal imaging and multimodal therapeutics against brain cancer cells. This theranostic agent was highly efficient in optical, photoacoustic and X-ray contrast imaging systems. The folate targeted NIR-responsive photothermal ablation in synergism with the chemotherapeutic action of doxorubicin proved to be a rapid precision guided cancer-killing module. The multi-stimuli, i.e., pH-, thermo- and photo-responsive drug release behavior of the nanoconjugates opens up a wider corridor for on-demand triggered drug administration. The simple synthesis protocol, combined with the multitudes of interesting features packed into a single nanoformulation, clearly demonstrates the competing role of this Cu2S nanosystem in future cancer treatment strategies.
UR - http://www.scopus.com/inward/record.url?scp=84928911061&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928911061&partnerID=8YFLogxK
U2 - 10.1039/c4nr07139e
DO - 10.1039/c4nr07139e
M3 - Article
C2 - 25797920
AN - SCOPUS:84928911061
SN - 2040-3364
VL - 7
SP - 8378
EP - 8388
JO - Nanoscale
JF - Nanoscale
IS - 18
ER -