Multi-stimuli responsive Cu2S nanocrystals as trimodal imaging and synergistic chemo-photothermal therapy agents

Aby Cheruvathoor Poulose, Srivani Veeranarayanan, M. Sheikh Mohamed, Yutaka Nagaoka, Rebeca Romero Aburto, Trevor Mitcham, Pulickel M. Ajayan, Richard R. Bouchard, Yasushi Sakamoto, Yasuhiko Yoshida, Toru Maekawa, D. Sakthi Kumar

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

A size and shape tuned, multifunctional metal chalcogenide, Cu2S-based nanotheranostic agent is developed for trimodal imaging and multimodal therapeutics against brain cancer cells. This theranostic agent was highly efficient in optical, photoacoustic and X-ray contrast imaging systems. The folate targeted NIR-responsive photothermal ablation in synergism with the chemotherapeutic action of doxorubicin proved to be a rapid precision guided cancer-killing module. The multi-stimuli, i.e., pH-, thermo- and photo-responsive drug release behavior of the nanoconjugates opens up a wider corridor for on-demand triggered drug administration. The simple synthesis protocol, combined with the multitudes of interesting features packed into a single nanoformulation, clearly demonstrates the competing role of this Cu2S nanosystem in future cancer treatment strategies.

Original languageEnglish (US)
Pages (from-to)8378-8388
Number of pages11
JournalNanoscale
Volume7
Issue number18
DOIs
StatePublished - May 14 2015

ASJC Scopus subject areas

  • General Materials Science

MD Anderson CCSG core facilities

  • Research Animal Support Facility
  • Small Animal Imaging Facility

Fingerprint

Dive into the research topics of 'Multi-stimuli responsive Cu2S nanocrystals as trimodal imaging and synergistic chemo-photothermal therapy agents'. Together they form a unique fingerprint.

Cite this