Multiclonal origin of polyps in Gardner syndrome

Susan H. Hsu; Gordon D. Luk; Anne J. Krush; Stanley R. Hamilton; Herbert H. Hoover

doi:10.1126/science.6879192

Multiclonal origin of polyps in Gardner syndrome

Susan H. Hsu, Gordon D. Luk, Anne J. Krush, Stanley R. Hamilton, Herbert H. Hoover

Graduate School of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

Electrophoretic analysis of glucose-6-phosphate dehydrogenase was performed on polyp tissue from three black female patients with Gardner syndrome and who are heterozygous for the A and B forms of this enzyme. Polyp tissues from the three patients displayed the AB phenotype. This finding suggests a multiclonal origin of polyps in Gardner syndrome. Studies of tumors originating from such polyps may provide information about the sequence of cellular events leading to malignant transformation.

Original language	English (US)
Pages (from-to)	951-953
Number of pages	3
Journal	Science
Volume	221
Issue number	4614
DOIs	https://doi.org/10.1126/science.6879192
State	Published - 1983

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title = "Multiclonal origin of polyps in Gardner syndrome",

abstract = "Electrophoretic analysis of glucose-6-phosphate dehydrogenase was performed on polyp tissue from three black female patients with Gardner syndrome and who are heterozygous for the A and B forms of this enzyme. Polyp tissues from the three patients displayed the AB phenotype. This finding suggests a multiclonal origin of polyps in Gardner syndrome. Studies of tumors originating from such polyps may provide information about the sequence of cellular events leading to malignant transformation.",

author = "Hsu, {Susan H.} and Luk, {Gordon D.} and Krush, {Anne J.} and Hamilton, {Stanley R.} and Hoover, {Herbert H.}",

year = "1983",

doi = "10.1126/science.6879192",

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journal = "Science",

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AU - Hsu, Susan H.

AU - Luk, Gordon D.

AU - Krush, Anne J.

AU - Hamilton, Stanley R.

AU - Hoover, Herbert H.

PY - 1983

Y1 - 1983

N2 - Electrophoretic analysis of glucose-6-phosphate dehydrogenase was performed on polyp tissue from three black female patients with Gardner syndrome and who are heterozygous for the A and B forms of this enzyme. Polyp tissues from the three patients displayed the AB phenotype. This finding suggests a multiclonal origin of polyps in Gardner syndrome. Studies of tumors originating from such polyps may provide information about the sequence of cellular events leading to malignant transformation.

AB - Electrophoretic analysis of glucose-6-phosphate dehydrogenase was performed on polyp tissue from three black female patients with Gardner syndrome and who are heterozygous for the A and B forms of this enzyme. Polyp tissues from the three patients displayed the AB phenotype. This finding suggests a multiclonal origin of polyps in Gardner syndrome. Studies of tumors originating from such polyps may provide information about the sequence of cellular events leading to malignant transformation.

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Multiclonal origin of polyps in Gardner syndrome

Abstract

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