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Multidrug Efflux Pumps Attenuate the Effect of MGMT Inhibitors
Karl Heinz Tomaszowski
, Ralf Schirrmacher
, Bernd Kaina
Research output
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Contribution to journal
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Article
›
peer-review
22
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Scopus citations
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Dive into the research topics of 'Multidrug Efflux Pumps Attenuate the Effect of MGMT Inhibitors'. Together they form a unique fingerprint.
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Keyphrases
Methylguanine Methyltransferase
100%
DNA Methyltransferase Inhibitor
100%
Multidrug Efflux Pump
100%
O6-benzylguanine
50%
Guanine
40%
Temozolomide
20%
Efflux
20%
ATP-binding Cassette Transporter A1 (ABCA1)
20%
Glucose Conjugates
20%
Tumor
10%
P-glycoprotein (P-gp)
10%
Cancer Cell Lines
10%
Cell Death
10%
Drug Transport
10%
Anticancer Drugs
10%
Cancer Cells
10%
DNA Repair
10%
Pharmacological Inhibitors
10%
DNA Repair Enzymes
10%
DNA Lesions
10%
Healthy Tissue
10%
O6-methylguanine-DNA Methyltransferase
10%
Repair Proteins
10%
Cancer Therapeutics
10%
DNA Hypomethylating Agents
10%
Lomustine
10%
Drug Resistance Mechanisms
10%
Alkylation
10%
Active Transport
10%
D-glucose
10%
Targeting Strategies
10%
High Demand
10%
Non-target Effects
10%
Efflux Inhibition
10%
Multidrug Resistance Protein 1 (MDR1)
10%
Efflux Transporters
10%
Pharmacology, Toxicology and Pharmaceutical Science
DNA Methyltransferase
100%
Effusion
100%
DNA Methyltransferase Inhibitor
100%
6 O Benzylguanine
57%
Guanine
57%
Glucose
57%
Malignant Neoplasm
42%
Temozolomide
28%
ABC Transporter
28%
Alkylating Agent
14%
Drug Transport
14%
Drug Resistance
14%
Anticarcinogen
14%
Methylated DNA Protein Cysteine Methyltransferase
14%
P-Glycoprotein
14%
Lomustine
14%
ABCG2
14%
6 O Methylguanine
14%
Multidrug Resistance Associated Protein 1
14%