Multiple Endocrine Neoplasia Syndromes

Glenda G. Callender, Thereasa A. Rich, Nancy Dugal Perrier

Research output: Contribution to journalReview article

48 Scopus citations

Abstract

The multiple endocrine neoplasia (MEN) syndromes are rare autosomal-dominant conditions that predispose affected individuals to benign and malignant tumors of the pituitary, thyroid, parathyroids, adrenals, endocrine pancreas, paraganglia, or nonendocrine organs. The classic MEN syndromes include MEN type 1 and MEN type 2. However, several other hereditary conditions should also be considered in the category of MEN: von Hippel-Lindau syndrome, the familial paraganglioma syndromes, Cowden syndrome, Carney complex, and hyperparathyroidism jaw-tumor syndrome. In addition, researchers are becoming aware of other familial endocrine neoplasia syndromes with an unknown genetic basis that might also fall into the category of MEN. This article reviews the clinical features, diagnosis, and surgical management of the various MEN syndromes and genetic risk assessment for patients presenting with one or more endocrine neoplasms.

Original languageEnglish (US)
Pages (from-to)863-895
Number of pages33
JournalSurgical Clinics of North America
Volume88
Issue number4
DOIs
StatePublished - Aug 1 2008

ASJC Scopus subject areas

  • Surgery

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