TY - JOUR
T1 - Multiwalled carbon nanotubes for combination therapy
T2 - A biodistribution and efficacy pilot study
AU - Biagiotti, Giacomo
AU - Pisaneschi, Federica
AU - Gammon, Seth T.
AU - Machetti, Fabrizio
AU - Ligi, Maria Cristina
AU - Giambastiani, Giuliano
AU - Tuci, Giulia
AU - Powell, Emily
AU - Piwnica-Worms, Helen
AU - Pranzini, Erica
AU - Paoli, Paolo
AU - Cicchi, Stefano
AU - Piwnica-Worms, David
N1 - Funding Information:
G. T. and S. C. thank Fondazione CR Firenze for its support to the HORIZON project. G. G. also thanks the ‘‘NanoMAX– Encoder’’ project (Engineering Nanostructures for Cellular Imaging and for Intracellular Delivery of Optically Active Drugs for Cardiac Hypertrophy) for supporting this work. S. C. thanks Ministero dell’Istruzione dell’Universitàe della Ricerca for the FIRB project ‘‘Approcci nanotecnologici per la teragnostica dei tumori’’. S. C. and P. P. thank AIRC (Associazione Italiana per la Ricerca sul cancro) for the project ‘‘Advanced mass spectrometry tools for cancer research: novel applications in proteomics, metabolomics and nanomedicine’’ (project code 19650) and for the project ‘‘Assaying tumor metabolic deregulation in live cells’’ (project code 19515). F. P. and S. T. G. thank the Small Animal Imaging Facility (SAIF) for assistance with PET/ CT imaging, a resource supported by the CCSG to MD Anderson Cancer Center (NIH P30CA016672). F. M. thanks Fondazione Cassa di Risparmio di Firenze for the project ‘‘Study on Catalytic Condensation of Nitro Compounds with alkenes and alkynes: a New Synthetic Method for Molecular Functionalisa-tion’’ (project code 2016.0868).
Publisher Copyright:
© 2019 The Royal Society of Chemistry.
PY - 2019
Y1 - 2019
N2 - A drug delivery system (DDS) for combined therapy, based on a short oxidized multiwalled carbon nanotube, is reported. It was prepared by exploiting a synthetic approach which allowed loading of two drugs, doxorubicin and metformin, the targeting agent biotin and a radiolabeling tag, to enable labeling with Ga-68 or Cu-64 in order to perform an extensive biodistribution study by PET/CT. The DDS biodistribution profile changes with different administration methods. Once administered at therapeutic doses, the DDS showed a marginal beneficial effect on 4T1 tumor bearing mice, a syngeneic and orthotopic model of triple negative breast cancer, with survival extended by 1 week and 2 days in 20% of the mice. This is encouraging given the aggressiveness of the 4T1 tumor. Furthermore, our DDS was well tolerated, ruling out concerns regarding the toxicity of carbon nanotubes.
AB - A drug delivery system (DDS) for combined therapy, based on a short oxidized multiwalled carbon nanotube, is reported. It was prepared by exploiting a synthetic approach which allowed loading of two drugs, doxorubicin and metformin, the targeting agent biotin and a radiolabeling tag, to enable labeling with Ga-68 or Cu-64 in order to perform an extensive biodistribution study by PET/CT. The DDS biodistribution profile changes with different administration methods. Once administered at therapeutic doses, the DDS showed a marginal beneficial effect on 4T1 tumor bearing mice, a syngeneic and orthotopic model of triple negative breast cancer, with survival extended by 1 week and 2 days in 20% of the mice. This is encouraging given the aggressiveness of the 4T1 tumor. Furthermore, our DDS was well tolerated, ruling out concerns regarding the toxicity of carbon nanotubes.
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U2 - 10.1039/c8tb03299h
DO - 10.1039/c8tb03299h
M3 - Article
C2 - 31073405
AN - SCOPUS:85064645913
SN - 2050-7518
VL - 7
SP - 2678
EP - 2687
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
IS - 16
ER -