TY - JOUR
T1 - Myocardial reperfusion can be predicted by myoglobin/creatine kinase ratio of a single blood sample obtained at the time of admission
AU - Abe, Junichi
AU - Yamaguchi, Tetsu
AU - Isshiki, Takaaki
AU - Naka, Hajime
AU - Taguchi, Junichi
AU - Ishizaka, Nobukazu
AU - Kurokawa, Kiyoshi
AU - Saeki, Fumihiko
AU - Ishizaka, Yuko
AU - Ui, Katsuto
AU - Ikari, Yuji
AU - Somitsu, Yasunari
AU - Hashimoto, Hideki
AU - Kashida, Mitsuo
PY - 1993/8
Y1 - 1993/8
N2 - To evaluate noninvasive markers for determining the reperfusion status without coronary angiography (CAG) or serial blood sampling in patients with acute myocardial infarction (AMI), two markers were examined: (1) serum myoglobin (Mb) level and (2) serum myoglobin/creatine kinase ratio (Mb/CK). Before emergency CAG a blood sample was drawn from 72 AMI patients within 6 hours after the onset of AMI. CAG revealed thrombolysis in myocardial infarction grades (TIMI) 0 to 1 in 56 and TIMI 2 to 3 in 16 patients (spontaneous reperfusion). No patients had received thrombolytic therapy before admission. TIMI 0 to 1 patients were characterized with lower Mb levels than TIMI 2 to 3 patients at admission (346 ± 476 vs 1558 ± 2005, mean ± SD, p < 0.001). Furthermore, the mean Mb0/CK0 ratio in TIMI 2 to 3 patients, who had already achieved the reperfusion at admission, was significantly higher than that in patients with TIMI 0 to 1 patients (6.5 ± 3.9 vs 2.1 ± 1.8, mean ± SD, p < 0.0001). When Mb0/CK0 >5.0 was assumed to indicate the sufficient reperfusion at admission, the sensitivity, specificity, and accuracy evaluating the reperfusion status were 75%, 96%, and 92%, respectively. It can be concluded that the reperfusion status can be predicted satisfactorily by a single blood sample obtained at the time of admission without CAG.
AB - To evaluate noninvasive markers for determining the reperfusion status without coronary angiography (CAG) or serial blood sampling in patients with acute myocardial infarction (AMI), two markers were examined: (1) serum myoglobin (Mb) level and (2) serum myoglobin/creatine kinase ratio (Mb/CK). Before emergency CAG a blood sample was drawn from 72 AMI patients within 6 hours after the onset of AMI. CAG revealed thrombolysis in myocardial infarction grades (TIMI) 0 to 1 in 56 and TIMI 2 to 3 in 16 patients (spontaneous reperfusion). No patients had received thrombolytic therapy before admission. TIMI 0 to 1 patients were characterized with lower Mb levels than TIMI 2 to 3 patients at admission (346 ± 476 vs 1558 ± 2005, mean ± SD, p < 0.001). Furthermore, the mean Mb0/CK0 ratio in TIMI 2 to 3 patients, who had already achieved the reperfusion at admission, was significantly higher than that in patients with TIMI 0 to 1 patients (6.5 ± 3.9 vs 2.1 ± 1.8, mean ± SD, p < 0.0001). When Mb0/CK0 >5.0 was assumed to indicate the sufficient reperfusion at admission, the sensitivity, specificity, and accuracy evaluating the reperfusion status were 75%, 96%, and 92%, respectively. It can be concluded that the reperfusion status can be predicted satisfactorily by a single blood sample obtained at the time of admission without CAG.
UR - http://www.scopus.com/inward/record.url?scp=0027270745&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027270745&partnerID=8YFLogxK
U2 - 10.1016/0002-8703(93)91040-L
DO - 10.1016/0002-8703(93)91040-L
M3 - Article
C2 - 8337996
AN - SCOPUS:0027270745
SN - 0002-8703
VL - 126
SP - 279
EP - 285
JO - American Heart Journal
JF - American Heart Journal
IS - 2
ER -