National trends in oropharyngeal cancer incidence and survival within the Veterans Affairs Health Care System

Jose P. Zevallos; Jennifer R. Kramer; Vlad C. Sandulache; Sean T. Massa; Christine M. Hartman; Angela L. Mazul; Benjamin M. Wahle; Sophie P. Gerndt; Erich M. Sturgis; Elizabeth Y. Chiao

doi:10.1002/hed.26465

National trends in oropharyngeal cancer incidence and survival within the Veterans Affairs Health Care System

Jose P. Zevallos, Jennifer R. Kramer, Vlad C. Sandulache, Sean T. Massa, Christine M. Hartman, Angela L. Mazul, Benjamin M. Wahle, Sophie P. Gerndt, Erich M. Sturgis, Elizabeth Y. Chiao

Head & Neck Surgery

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11 Scopus citations

Abstract

Background: Oropharyngeal squamous cell carcinoma (OPSCC) epidemiology has not been examined previously in the nationwide Veterans Affairs (VA) population. Methods: Joinpoint regression analysis was applied to OPSCC cases identified from VA administrative data from 2000 to 2012. Results: We identified 12 125 OPSCC cases (incidence: 12.2 of 100 000 persons). OPSCC incidence declined between 2000 and 2006 (annual percent change [APC] = −4.27, P <.05), then increased between 2006 and 2012 (APC = 7.02, P <.05). Significant incidence increases occurred among white (APC = 7.19, P <.05) and African American (APC = 4.87, P <.05) Veterans and across all age cohorts. The percentage of never-smokers increased from 8% in 2000 to 15.7% in 2012 (P <.001), and 2-year overall survival improved from 31.2% (95% confidence interval (CI) [30-33.4]) to 55.7% (95% CI [54.4-57.1]). Conclusions: OPSCC incidence is increasing across all racial and age cohorts in the VA population. Smoking rates remain high among Veterans with OPSCC and gains in survival lag those reported in the general population.

Original language	English (US)
Pages (from-to)	108-115
Number of pages	8
Journal	Head and Neck
Volume	43
Issue number	1
DOIs	https://doi.org/10.1002/hed.26465
State	Published - Jan 2021

Keywords

Veterans Affairs
human papilloma virus
joinpoint
oropharyngeal cancer
survival

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.26465

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title = "National trends in oropharyngeal cancer incidence and survival within the Veterans Affairs Health Care System",

abstract = "Background: Oropharyngeal squamous cell carcinoma (OPSCC) epidemiology has not been examined previously in the nationwide Veterans Affairs (VA) population. Methods: Joinpoint regression analysis was applied to OPSCC cases identified from VA administrative data from 2000 to 2012. Results: We identified 12 125 OPSCC cases (incidence: 12.2 of 100 000 persons). OPSCC incidence declined between 2000 and 2006 (annual percent change [APC] = −4.27, P <.05), then increased between 2006 and 2012 (APC = 7.02, P <.05). Significant incidence increases occurred among white (APC = 7.19, P <.05) and African American (APC = 4.87, P <.05) Veterans and across all age cohorts. The percentage of never-smokers increased from 8% in 2000 to 15.7% in 2012 (P <.001), and 2-year overall survival improved from 31.2% (95% confidence interval (CI) [30-33.4]) to 55.7% (95% CI [54.4-57.1]). Conclusions: OPSCC incidence is increasing across all racial and age cohorts in the VA population. Smoking rates remain high among Veterans with OPSCC and gains in survival lag those reported in the general population.",

keywords = "Veterans Affairs, human papilloma virus, joinpoint, oropharyngeal cancer, survival",

author = "Zevallos, {Jose P.} and Kramer, {Jennifer R.} and Sandulache, {Vlad C.} and Massa, {Sean T.} and Hartman, {Christine M.} and Mazul, {Angela L.} and Wahle, {Benjamin M.} and Gerndt, {Sophie P.} and Sturgis, {Erich M.} and Chiao, {Elizabeth Y.}",

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year = "2021",

month = jan,

doi = "10.1002/hed.26465",

language = "English (US)",

volume = "43",

pages = "108--115",

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T1 - National trends in oropharyngeal cancer incidence and survival within the Veterans Affairs Health Care System

AU - Zevallos, Jose P.

AU - Kramer, Jennifer R.

AU - Sandulache, Vlad C.

AU - Massa, Sean T.

AU - Hartman, Christine M.

AU - Mazul, Angela L.

AU - Wahle, Benjamin M.

AU - Gerndt, Sophie P.

AU - Sturgis, Erich M.

AU - Chiao, Elizabeth Y.

PY - 2021/1

Y1 - 2021/1

N2 - Background: Oropharyngeal squamous cell carcinoma (OPSCC) epidemiology has not been examined previously in the nationwide Veterans Affairs (VA) population. Methods: Joinpoint regression analysis was applied to OPSCC cases identified from VA administrative data from 2000 to 2012. Results: We identified 12 125 OPSCC cases (incidence: 12.2 of 100 000 persons). OPSCC incidence declined between 2000 and 2006 (annual percent change [APC] = −4.27, P <.05), then increased between 2006 and 2012 (APC = 7.02, P <.05). Significant incidence increases occurred among white (APC = 7.19, P <.05) and African American (APC = 4.87, P <.05) Veterans and across all age cohorts. The percentage of never-smokers increased from 8% in 2000 to 15.7% in 2012 (P <.001), and 2-year overall survival improved from 31.2% (95% confidence interval (CI) [30-33.4]) to 55.7% (95% CI [54.4-57.1]). Conclusions: OPSCC incidence is increasing across all racial and age cohorts in the VA population. Smoking rates remain high among Veterans with OPSCC and gains in survival lag those reported in the general population.

AB - Background: Oropharyngeal squamous cell carcinoma (OPSCC) epidemiology has not been examined previously in the nationwide Veterans Affairs (VA) population. Methods: Joinpoint regression analysis was applied to OPSCC cases identified from VA administrative data from 2000 to 2012. Results: We identified 12 125 OPSCC cases (incidence: 12.2 of 100 000 persons). OPSCC incidence declined between 2000 and 2006 (annual percent change [APC] = −4.27, P <.05), then increased between 2006 and 2012 (APC = 7.02, P <.05). Significant incidence increases occurred among white (APC = 7.19, P <.05) and African American (APC = 4.87, P <.05) Veterans and across all age cohorts. The percentage of never-smokers increased from 8% in 2000 to 15.7% in 2012 (P <.001), and 2-year overall survival improved from 31.2% (95% confidence interval (CI) [30-33.4]) to 55.7% (95% CI [54.4-57.1]). Conclusions: OPSCC incidence is increasing across all racial and age cohorts in the VA population. Smoking rates remain high among Veterans with OPSCC and gains in survival lag those reported in the general population.

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KW - human papilloma virus

KW - joinpoint

KW - oropharyngeal cancer

KW - survival

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National trends in oropharyngeal cancer incidence and survival within the Veterans Affairs Health Care System

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