ncRNA therapy with miRNA-22-3p suppresses the growth of triple-negative breast cancer

Aysegul Gorur; Recep Bayraktar; Cristina Ivan; Hamada Ahmed Mokhlis; Emine Bayraktar; Nermin Kahraman; Didem Karakas; Selda Karamil; Nashwa N. Kabil; Pinar Kanlikilicer; Burcu Aslan; Lulufer Tamer; Zhihui Wang; Vittorio Cristini; Gabriel Lopez-Berestein; George Calin; Bulent Ozpolat

doi:10.1016/j.omtn.2021.01.016

ncRNA therapy with miRNA-22-3p suppresses the growth of triple-negative breast cancer

Aysegul Gorur, Recep Bayraktar, Cristina Ivan, Hamada Ahmed Mokhlis, Emine Bayraktar, Nermin Kahraman, Didem Karakas, Selda Karamil, Nashwa N. Kabil, Pinar Kanlikilicer, Burcu Aslan, Lulufer Tamer, Zhihui Wang, Vittorio Cristini, Gabriel Lopez-Berestein, George Calin, Bulent Ozpolat

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Our study demonstrates that microRNA-22-3p (miR-22-3p) acts as a tumor suppressor in which its expression is markedly reduced in TNBC tumors. Restoration of its expression by miR-22-3p nanotherapy suppress tumor growth and progression by directly inhibiting of eEF2K-PI3K/AKT and Src signaling. miR-22-3p-based RNA therapy may be novel treatment for TNBC.

Original language	English (US)
Pages (from-to)	930-943
Number of pages	14
Journal	Molecular Therapy Nucleic Acids
Volume	23
DOIs	https://doi.org/10.1016/j.omtn.2021.01.016
State	Published - Mar 5 2021

Keywords

Akt
EF2K
PI3K
Src
breast cancer
eEF2K
gene regulation
gene silencing
liposomes
miR-22
nanoparticles
therapy
triple-negative breast cancer
tumor suppressor

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1016/j.omtn.2021.01.016

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Gorur, A., Bayraktar, R., Ivan, C., Mokhlis, H. A., Bayraktar, E., Kahraman, N., Karakas, D., Karamil, S., Kabil, N. N., Kanlikilicer, P., Aslan, B., Tamer, L., Wang, Z., Cristini, V., Lopez-Berestein, G., Calin, G., & Ozpolat, B. (2021). ncRNA therapy with miRNA-22-3p suppresses the growth of triple-negative breast cancer. Molecular Therapy Nucleic Acids, 23, 930-943. https://doi.org/10.1016/j.omtn.2021.01.016

Gorur, A, Bayraktar, R, Ivan, C, Mokhlis, HA, Bayraktar, E, Kahraman, N, Karakas, D, Karamil, S, Kabil, NN, Kanlikilicer, P, Aslan, B, Tamer, L, Wang, Z, Cristini, V, Lopez-Berestein, G , Calin, G & Ozpolat, B 2021, 'ncRNA therapy with miRNA-22-3p suppresses the growth of triple-negative breast cancer', Molecular Therapy Nucleic Acids, vol. 23, pp. 930-943. https://doi.org/10.1016/j.omtn.2021.01.016

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title = "ncRNA therapy with miRNA-22-3p suppresses the growth of triple-negative breast cancer",

abstract = "Our study demonstrates that microRNA-22-3p (miR-22-3p) acts as a tumor suppressor in which its expression is markedly reduced in TNBC tumors. Restoration of its expression by miR-22-3p nanotherapy suppress tumor growth and progression by directly inhibiting of eEF2K-PI3K/AKT and Src signaling. miR-22-3p-based RNA therapy may be novel treatment for TNBC.",

keywords = "Akt, EF2K, PI3K, Src, breast cancer, eEF2K, gene regulation, gene silencing, liposomes, miR-22, nanoparticles, therapy, triple-negative breast cancer, tumor suppressor",

author = "Aysegul Gorur and Recep Bayraktar and Cristina Ivan and Mokhlis, {Hamada Ahmed} and Emine Bayraktar and Nermin Kahraman and Didem Karakas and Selda Karamil and Kabil, {Nashwa N.} and Pinar Kanlikilicer and Burcu Aslan and Lulufer Tamer and Zhihui Wang and Vittorio Cristini and Gabriel Lopez-Berestein and George Calin and Bulent Ozpolat",

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doi = "10.1016/j.omtn.2021.01.016",

language = "English (US)",

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AU - Gorur, Aysegul

AU - Bayraktar, Recep

AU - Ivan, Cristina

AU - Mokhlis, Hamada Ahmed

AU - Bayraktar, Emine

AU - Kahraman, Nermin

AU - Karakas, Didem

AU - Karamil, Selda

AU - Kabil, Nashwa N.

AU - Kanlikilicer, Pinar

AU - Aslan, Burcu

AU - Tamer, Lulufer

AU - Wang, Zhihui

AU - Cristini, Vittorio

AU - Lopez-Berestein, Gabriel

AU - Calin, George

AU - Ozpolat, Bulent

PY - 2021/3/5

Y1 - 2021/3/5

N2 - Our study demonstrates that microRNA-22-3p (miR-22-3p) acts as a tumor suppressor in which its expression is markedly reduced in TNBC tumors. Restoration of its expression by miR-22-3p nanotherapy suppress tumor growth and progression by directly inhibiting of eEF2K-PI3K/AKT and Src signaling. miR-22-3p-based RNA therapy may be novel treatment for TNBC.

AB - Our study demonstrates that microRNA-22-3p (miR-22-3p) acts as a tumor suppressor in which its expression is markedly reduced in TNBC tumors. Restoration of its expression by miR-22-3p nanotherapy suppress tumor growth and progression by directly inhibiting of eEF2K-PI3K/AKT and Src signaling. miR-22-3p-based RNA therapy may be novel treatment for TNBC.

KW - Akt

KW - EF2K

KW - PI3K

KW - Src

KW - breast cancer

KW - eEF2K

KW - gene regulation

KW - gene silencing

KW - liposomes

KW - miR-22

KW - nanoparticles

KW - therapy

KW - triple-negative breast cancer

KW - tumor suppressor

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DO - 10.1016/j.omtn.2021.01.016

M3 - Article

C2 - 33614241

AN - SCOPUS:85100401048

SN - 2162-2531

VL - 23

SP - 930

EP - 943

JO - Molecular Therapy Nucleic Acids

JF - Molecular Therapy Nucleic Acids

ER -

ncRNA therapy with miRNA-22-3p suppresses the growth of triple-negative breast cancer

Abstract

Keywords

ASJC Scopus subject areas

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