Near real time confocal imaging of dysplasia in the oral cavity

A. L. Clark, A. Gillenwater, T. Collier, R. Alizadeh-Naderi, A. K. El-Naggar, R. Richards-Kortum

Research output: Contribution to journalConference articlepeer-review


The use of high resolution, in vivo confocal imaging may offer a clinical tool to detect early neoplasia and reduce the incidence and mortality of cancer. Our laboratory is currently examining the feasibility of using confocal microscopy for non-invasive diagnosis of dysplasia and early carcinoma in the oral cavity. This study uses a near real time reflectance confocal microscope to acquire images at various depths throughout the epithelial layer. To date, we have examined data from twelve of an approved twenty-two patient study in the oral cavity. Our initial results demonstrate the confocal microscope's ability to image sub-cellular morphology with a resolution allowing differentiation between normal and dysplastic tissue. These results support this technique's potential for in vivo assessment of dysplasia within the oral cavity.

Original languageEnglish (US)
Pages (from-to)982-983
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
StatePublished - 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002


  • Biomedical imaging
  • Cancer detection
  • Confocal microscopy
  • Neoplasia

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics


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