Abstract
The use of high resolution, in vivo confocal imaging may offer a clinical tool to detect early neoplasia and reduce the incidence and mortality of cancer. Our laboratory is currently examining the feasibility of using confocal microscopy for non-invasive diagnosis of dysplasia and early carcinoma in the oral cavity. This study uses a near real time reflectance confocal microscope to acquire images at various depths throughout the epithelial layer. To date, we have examined data from twelve of an approved twenty-two patient study in the oral cavity. Our initial results demonstrate the confocal microscope's ability to image sub-cellular morphology with a resolution allowing differentiation between normal and dysplastic tissue. These results support this technique's potential for in vivo assessment of dysplasia within the oral cavity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 982-983 |
| Number of pages | 2 |
| Journal | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
| Volume | 2 |
| State | Published - 2002 |
| Event | Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States Duration: Oct 23 2002 → Oct 26 2002 |
Keywords
- Biomedical imaging
- Cancer detection
- Confocal microscopy
- Neoplasia
ASJC Scopus subject areas
- Signal Processing
- Biomedical Engineering
- Computer Vision and Pattern Recognition
- Health Informatics