Abstract
Invasive carcinoma of the uterine cervix is preceded by a number of morphological intraepithelial changes. Real-time confocal microscopy has been demonstrated to be successful in imaging subcellular detail in-vivo. The purpose of this pilot study is to image ex-vivo tissue using a near real time confocal microscope and determine whether the images can be used to distinguish between normal and dysplastic tissue. Biopsies from 19 patients were imaged at various depths with our confocal microscope. Nuclear morphologic features were extracted from the confocal images. The morphologic feature measurements compare well with the pathologic examination. Discriminating the images for the presence of dysplasia using morphologic feature detection resulted in a sensitivity and specificity of 100% and 91%, respectively.
Original language | English (US) |
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Pages (from-to) | 979-981 |
Number of pages | 3 |
Journal | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
Volume | 2 |
State | Published - 2002 |
Event | Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States Duration: Oct 23 2002 → Oct 26 2002 |
Keywords
- Amelanotic tissue
- Confocal microscopy
- Dysplasia
ASJC Scopus subject areas
- Signal Processing
- Biomedical Engineering
- Computer Vision and Pattern Recognition
- Health Informatics