Necrotizing Pancreatitis Related to Immune Checkpoint Inhibitor Therapy

Sidra Naz; Yinghong Wang; Suresh Chari; Anusha S. Thomas; Sireesha Yedururi

doi:10.1007/978-3-031-83533-9_47

Necrotizing Pancreatitis Related to Immune Checkpoint Inhibitor Therapy

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

This is a case with Merkel cell carcinoma, received 6 doses of avelumab with subsequent severe necrotizing pancreatitis. The disease course after steroid treatment was complicated with pancreatic abscess/fistula and sepsis requiring prolonged antibiotics, frequent drain placement and long term TPN. Patient ultimately recovered from the event after 1 year. Over the follow up of 2 years, patient developed asymptomatic pancreatic atrophy, with cancer in remission despite ICI termination.

Original language	English (US)
Title of host publication	Challenging Cases in Immunotherapy Related Organ Toxicities
Publisher	Springer Science+Business Media
Pages	369-374
Number of pages	6
ISBN (Electronic)	9783031835339
ISBN (Print)	9783031835322
DOIs	https://doi.org/10.1007/978-3-031-83533-9_47
State	Published - Jan 1 2025

Keywords

Adverse event
Contrast-enhanced computed tomography (CT) imaging
Immune checkpoint inhibitors
Pancreatitis
Toxicity

ASJC Scopus subject areas

General Medicine

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10.1007/978-3-031-83533-9_47

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title = "Necrotizing Pancreatitis Related to Immune Checkpoint Inhibitor Therapy",

abstract = "This is a case with Merkel cell carcinoma, received 6 doses of avelumab with subsequent severe necrotizing pancreatitis. The disease course after steroid treatment was complicated with pancreatic abscess/fistula and sepsis requiring prolonged antibiotics, frequent drain placement and long term TPN. Patient ultimately recovered from the event after 1 year. Over the follow up of 2 years, patient developed asymptomatic pancreatic atrophy, with cancer in remission despite ICI termination.",

keywords = "Adverse event, Contrast-enhanced computed tomography (CT) imaging, Immune checkpoint inhibitors, Pancreatitis, Toxicity",

author = "Sidra Naz and Yinghong Wang and Suresh Chari and Thomas, \{Anusha S.\} and Sireesha Yedururi",

note = "Publisher Copyright: {\textcopyright} 2025 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG.",

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T1 - Necrotizing Pancreatitis Related to Immune Checkpoint Inhibitor Therapy

AU - Naz, Sidra

AU - Wang, Yinghong

AU - Chari, Suresh

AU - Thomas, Anusha S.

AU - Yedururi, Sireesha

PY - 2025/1/1

Y1 - 2025/1/1

N2 - This is a case with Merkel cell carcinoma, received 6 doses of avelumab with subsequent severe necrotizing pancreatitis. The disease course after steroid treatment was complicated with pancreatic abscess/fistula and sepsis requiring prolonged antibiotics, frequent drain placement and long term TPN. Patient ultimately recovered from the event after 1 year. Over the follow up of 2 years, patient developed asymptomatic pancreatic atrophy, with cancer in remission despite ICI termination.

AB - This is a case with Merkel cell carcinoma, received 6 doses of avelumab with subsequent severe necrotizing pancreatitis. The disease course after steroid treatment was complicated with pancreatic abscess/fistula and sepsis requiring prolonged antibiotics, frequent drain placement and long term TPN. Patient ultimately recovered from the event after 1 year. Over the follow up of 2 years, patient developed asymptomatic pancreatic atrophy, with cancer in remission despite ICI termination.

KW - Adverse event

KW - Contrast-enhanced computed tomography (CT) imaging

KW - Immune checkpoint inhibitors

KW - Pancreatitis

KW - Toxicity

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UR - https://www.scopus.com/pages/publications/105022227128#tab=citedBy

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M3 - Chapter

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EP - 374

BT - Challenging Cases in Immunotherapy Related Organ Toxicities

PB - Springer Science+Business Media

ER -

Necrotizing Pancreatitis Related to Immune Checkpoint Inhibitor Therapy

Abstract

Keywords

ASJC Scopus subject areas

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