TY - JOUR
T1 - NEDD8 Pathways in Cancer, Sine Quibus Non
AU - Watson, Ian R.
AU - Irwin, Meredith S.
AU - Ohh, Michael
N1 - Funding Information:
Our research was supported by funds from the Canadian Cancer Society (18460 and 20110 to M.O. and 18054 to M.S.I.). I.R.W. is a recipient of the Canadian Institutes of Health Research (CIHR) Canada Graduate Scholarship. M.O. and M.S.I. are Canada Research Chairs. We apologize to those whose work could not be cited due to space restrictions.
PY - 2011/2/15
Y1 - 2011/2/15
N2 - There are 17 known ubiquitin-like proteins (UBLs) from nine phylogenetically distinct classes (NEDD8, SUMO, ISG15, FUB1, FAT10, Atg8, Atg12, Urm1, and UFM1) that have been identified to conjugate to substrates in a manner analogous to ubiquitin. NEDD8 is one of the most studied UBLs and shares the highest amino acid similarity to ubiquitin. Here, we review the current knowledge of the NEDD8 conjugation cascade derived from functional studies in genetic model organisms, structural insights from crystallographic studies, biochemical studies identifying a growing list of NEDD8 substrates with oncogenic implications, and attempts to pharmacologically target the NEDD8 pathway in cancer.
AB - There are 17 known ubiquitin-like proteins (UBLs) from nine phylogenetically distinct classes (NEDD8, SUMO, ISG15, FUB1, FAT10, Atg8, Atg12, Urm1, and UFM1) that have been identified to conjugate to substrates in a manner analogous to ubiquitin. NEDD8 is one of the most studied UBLs and shares the highest amino acid similarity to ubiquitin. Here, we review the current knowledge of the NEDD8 conjugation cascade derived from functional studies in genetic model organisms, structural insights from crystallographic studies, biochemical studies identifying a growing list of NEDD8 substrates with oncogenic implications, and attempts to pharmacologically target the NEDD8 pathway in cancer.
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U2 - 10.1016/j.ccr.2011.01.002
DO - 10.1016/j.ccr.2011.01.002
M3 - Review article
C2 - 21316600
AN - SCOPUS:79751469547
SN - 1535-6108
VL - 19
SP - 168
EP - 176
JO - Cancer cell
JF - Cancer cell
IS - 2
ER -