Neoadjuvant therapy in the treatment of breast cancer

Mediget Teshome, Kelly K. Hunt

Research output: Contribution to journalReview articlepeer-review

98 Scopus citations

Abstract

Neoadjuvant systemic therapy in breast cancer treatment was initially utilized for inoperable disease. However, several randomized prospective studies have demonstrated comparable survival with adjuvant chemotherapy in early-stage, operable breast cancer while also decreasing tumor size facilitating breast conservation without significant increases in local recurrence. Response to therapy can predict outcome, with improved survival associated with pathologic complete response (pCR). Triple negative and HER2-positive subtypes show increased pCR rates. A multidisciplinary approach is necessary with neoadjuvant treatment. This can improve rates of breast conservation, provide insights into tumor biology and predict patient outcomes.

Original languageEnglish (US)
Pages (from-to)505-523
Number of pages19
JournalSurgical oncology clinics of North America
Volume23
Issue number3
DOIs
StatePublished - Jul 2014

Keywords

  • Breast cancer
  • Neoadjuvant chemotherapy
  • Pathologic complete response
  • Preoperative chemotherapy

ASJC Scopus subject areas

  • Surgery
  • Oncology

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