Neural reprogramming via microRNAs: the new kid on the p53-deficient block

Research output: Contribution to journalArticlepeer-review

Abstract

We recently reported a novel role for nerve-cancer crosstalk, demonstrating that tumor protein p53 (TP53) deficiency in head and neck squamous cell carcinoma leads to a decrease in miR-34a in tumor-shed vesicles. This directed sensory nerve reprogramming in the tumor microenvironment which enhanced tumor growth.

Original languageEnglish (US)
Article number1756723
JournalMolecular and Cellular Oncology
Volume7
Issue number4
DOIs
StatePublished - Jul 3 2020

Keywords

  • TP53
  • adrenergic signaling
  • head and neck cancer
  • miR-34a
  • microRNA
  • neural reprogramming
  • p53
  • tumor microenvironment

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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