Neural Stem Cells - Therapeutic Applications in Neurodegenerative Diseases

Rodolfo Gonzalez, Yang D. Teng, Kook I. Park, Jean Pyo Lee, Jitka Ourednik, Vaclav Ourednik, Jaimie Imitola, Franz Josef Mueller, Richard L. Sidman, Evan Y. Snyder

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Although endogenous neural stem cells (NSCs) exist in the mammalian brain, intrinsic 'self- repair' activity for the most devastating of injuries is inadequate or ineffective. This poor 'regenerative' ability, particularly in the adult central nervous system (CNS), may be because of the limited number and restricted location of native NSCs and/or limitations imposed by the surrounding microenvironment, which may not be supportive or instructive of neuronal differentiation. NSCs expanded ex vivo and then implanted into regions needing repair may overcome those limitations related simply to inadequate numbers of NSCs near the defective region. It is possible that the environment may also inhibit exogenous NSCs from surviving or differentiating toward replacement cells. However, transplantation experiments have revealed that NSCs appear to respond in vivo to neurogenic signals, not only when they occur appropriately during development, but even when induced at later stages by certain neurodegenerative processes.

    Original languageEnglish (US)
    Title of host publicationEssentials of Stem Cell Biology
    Subtitle of host publicationThird Edition
    PublisherElsevier Inc.
    Pages467-489
    Number of pages23
    ISBN (Electronic)9780124104273
    ISBN (Print)9780124095038
    DOIs
    StatePublished - Jan 1 2014

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    Keywords

    • Animal models of neurodegeneration
    • Brain integration
    • C-myc
    • Delivery strategies
    • Ex vivo expansion
    • Neural stem cells

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Gonzalez, R., Teng, Y. D., Park, K. I., Lee, J. P., Ourednik, J., Ourednik, V., Imitola, J., Mueller, F. J., Sidman, R. L., & Snyder, E. Y. (2014). Neural Stem Cells - Therapeutic Applications in Neurodegenerative Diseases. In Essentials of Stem Cell Biology: Third Edition (pp. 467-489). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-409503-8.00032-9