Abstract
Background: There is little data describing neurocognitive late sequelae in patients treated for oropharyngeal cancer. Methods: Using PROs, scores for “numbness/tingling” and “difficulty remembering” were assessed. Wilcoxon testing was utilized to compare mean assessment scores (1-10) between treatment subgroups. Results: Four-hundred ninety-seven patients were evaluated and 267 (54%) received chemotherapy. The mean score for numbness/tingling for patients receiving radiation alone was 0.99 and for each chemotherapy subgroup were: Induction chemotherapy (IC), 1.35 (n = 99); concurrent chemotherapy (CCRT), 1.04 (n = 111) and IC + CCRT, 2.48 (n = 57); 30% of patients who received IC + CCRT had scores ≥5. The mean scores for difficulty remembering were XRT: 1.44, chemotherapy: 1.45, and IC + CCRT subgroup: 2.42. Conclusions: The symptom burden related to peripheral neuropathy and cognitive complaints was minimal. A minority of patients reported high burdens. Particularly, 30% of patients receiving IC + CCRT described moderate to severe numbness/tingling.
Original language | English (US) |
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Pages (from-to) | 2137-2144 |
Number of pages | 8 |
Journal | Head and Neck |
Volume | 42 |
Issue number | 8 |
DOIs | |
State | Published - Aug 1 2020 |
Keywords
- chemoradiation
- cisplatin
- radiation
- taxane
ASJC Scopus subject areas
- Otorhinolaryngology