TY - JOUR
T1 - New directions in reducing stress effects on cancer
AU - Melhem-Bertrandt, Amal
AU - Sood, Anil K.
PY - 2012/2
Y1 - 2012/2
N2 - A growing body of evidence is now connecting neuroendocrine mediators of the stress response to cancer biology. Al-Wadei and colleagues report a study in this issue of the journal (beginning on page 189) that provides a new piece of this evidence, adding the inhibitory neurotransmitter γ-aminobutyric acid to this intricate pathway. Their mouse model study supports the hypothesis that stress mediators contribute to lung cancer progression and that known inhibitors of the stress pathway might block such effects, thus adding to the impetus for studying cancer prevention strategies targeting the stress pathway.
AB - A growing body of evidence is now connecting neuroendocrine mediators of the stress response to cancer biology. Al-Wadei and colleagues report a study in this issue of the journal (beginning on page 189) that provides a new piece of this evidence, adding the inhibitory neurotransmitter γ-aminobutyric acid to this intricate pathway. Their mouse model study supports the hypothesis that stress mediators contribute to lung cancer progression and that known inhibitors of the stress pathway might block such effects, thus adding to the impetus for studying cancer prevention strategies targeting the stress pathway.
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U2 - 10.1158/1940-6207.CAPR-11-0579
DO - 10.1158/1940-6207.CAPR-11-0579
M3 - Review article
C2 - 22307563
AN - SCOPUS:84857681523
SN - 1940-6207
VL - 5
SP - 147
EP - 149
JO - Cancer Prevention Research
JF - Cancer Prevention Research
IS - 2
ER -