New insights into long non-coding rna malat1 in cancer and metastasis

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is one of the most abundant, long non-coding RNAs (lncRNAs) in normal tissues. This lncRNA is highly conserved among mammalian species, and based on in vitro results, has been reported to regulate alternative pre-mRNA splicing and gene expression. However, Malat1 knockout mice develop and grow normally, and do not show alterations in alternative splicing. While MALAT1 was originally described as a prognostic marker of lung cancer metastasis, emerging evidence has linked this lncRNA to other cancers, such as breast cancer, prostate cancer, pancreatic cancer, glioma, and leukemia. The role described for MALAT1 is dependent on the cancer types and the experimental model systems. Notably, different or opposite phenotypes resulting from different strategies for inactivating MALAT1 have been observed, which led to distinct models for MALAT1′s functions and mechanisms of action in cancer and metastasis. In this review, we reflect on different experimental strategies used to study MALAT1′s functions, and discuss the current mechanistic models of this highly abundant and conserved lncRNA.

Original languageEnglish (US)
Article number216
JournalCancers
Volume11
Issue number2
DOIs
StatePublished - Feb 1 2019

Fingerprint

Long Noncoding RNA
Neoplasm Metastasis
Neoplasms
Prostatic Neoplasms
RNA Precursors
Alternative Splicing
Pancreatic Neoplasms
Knockout Mice
Glioma
Lung Neoplasms
Leukemia
Theoretical Models
Breast Neoplasms
Phenotype
Gene Expression
Adenocarcinoma of lung

Keywords

  • LncRNA
  • MALAT1
  • Metastasis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

New insights into long non-coding rna malat1 in cancer and metastasis. / Sun, Yutong; Ma, Li.

In: Cancers, Vol. 11, No. 2, 216, 01.02.2019.

Research output: Contribution to journalReview article

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