New prognostic factors affecting response and survival in adult acute leukemia

E. J. Freireich, E. A. Gehan, G. P. Bodey

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The authors have ranked in order of importance pretreatment variables for predicting response, duration of response and survival. In a group of patients with acute leukemia, excellent predictions were obtained using the 14 conventional clinical variables. New variables have been discovered which have greater predictive value than age, infection status, and degree of leukemic infiltration. The first measurement of proliferating fraction by in vitro incorporation of thymidine, contributes significantly to the probability of response and is the best factor for predicting duration of remission for patients already in remission. Secondly, immunocompetence is of greater prognostic significance than either age or morphological diagnosis. And finally, a new test involving the detection of leukemic antigen in remission bone marrow provides a powerful technique for predicting duration of response. The addition of these new prognostic tests offers great promise for further improving ability to make comparisons between groups of patients undergoing experimental therapy.

Original languageEnglish (US)
Pages (from-to)298-305
Number of pages8
JournalTransactions of the Association of American Physicians
Volume87
StatePublished - 1974

ASJC Scopus subject areas

  • General Medicine

Fingerprint

Dive into the research topics of 'New prognostic factors affecting response and survival in adult acute leukemia'. Together they form a unique fingerprint.

Cite this