New therapeutic targets in soft tissue sarcoma

Elizabeth G. Demicco, Robert G. Maki, Dina C. Lev, Alexander J. Lazar

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations

Abstract

Soft tissue sarcomas are an uncommon and diverse group of more than 50 mesenchymal malignancies. The pathogenesis of many of these is poorly understood, but others have begun to reveal the secrets of their underlying mechanisms. With considerable effort over recent years, soft tissue sarcomas have increasingly been classified on the basis of underlying molecular alterations. In turn, this has allowed the development and application of targeted agents in several specific, molecularly defined, sarcoma subtypes. This review will focus on the rationale for targeted therapy in sarcoma, with emphasis on the relevance of specific molecular factors and pathways in both translocation-associated sarcomas and in genetically complex tumors. In addition, we will address some of the early successes in sarcoma-targeted therapy as well as a few challenges and disappointments in this field. Finally, we will discuss several possible opportunities represented by poorly understood, but potentially promising new therapeutic targets, as well as several novel biological agents currently in preclinical and early phase I/II trials. This will provide the reader with the context for understanding the current state of this field and a sense of where it may be headed in the coming years.

Original languageEnglish (US)
Pages (from-to)170-180
Number of pages11
JournalAdvances in anatomic pathology
Volume19
Issue number3
DOIs
StatePublished - May 2012

Keywords

  • molecular mechanisms
  • soft tissue sarcoma
  • targeted therapy

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

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