TY - JOUR
T1 - Nitroglycerin-Citrate-Ethanol Catheter Lock Solution Is Highly Effective for in Vitro Eradication of Candida auris Biofilm
AU - Vargas-Cruz, Nylev
AU - Reitzel, Ruth A.
AU - Rosenblatt, Joel
AU - Chaftari, Anne Marie
AU - Dib, Rita Wilson
AU - Hachem, Ray
AU - Kontoyiannis, Dimitrios P.
AU - Raad, Issam I.
N1 - Publisher Copyright:
© 2019 American Society for Microbiology. All Rights Reserved.
PY - 2019
Y1 - 2019
N2 - Candida auris poses emerging risks for causing severe central line-associated bloodstream infections. We tested in vitro the ability of antifungal lock solutions to rapidly eradicate C. auris biofilms. Liposomal amphotericin B, amphotericin B deoxycholate, fluconazole, voriconazole, micafungin, caspofungin, and anidulafungin failed to completely eradicate all 10 tested C. auris biofilms. Conversely, nitroglycerin-citrate-ethanol (NiCE) catheter lock solution completely eradicated all replicates for all of C. auris biofilms tested.
AB - Candida auris poses emerging risks for causing severe central line-associated bloodstream infections. We tested in vitro the ability of antifungal lock solutions to rapidly eradicate C. auris biofilms. Liposomal amphotericin B, amphotericin B deoxycholate, fluconazole, voriconazole, micafungin, caspofungin, and anidulafungin failed to completely eradicate all 10 tested C. auris biofilms. Conversely, nitroglycerin-citrate-ethanol (NiCE) catheter lock solution completely eradicated all replicates for all of C. auris biofilms tested.
KW - Biofilm
KW - Candida auris
KW - Catheter lock solution
KW - Nitroglycerin-citrate-ethanol
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UR - http://www.scopus.com/inward/citedby.url?scp=85068151279&partnerID=8YFLogxK
U2 - 10.1128/AAC.00299-19
DO - 10.1128/AAC.00299-19
M3 - Article
C2 - 31036689
AN - SCOPUS:85068151279
SN - 0066-4804
VL - 63
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 7
M1 - e00299-19
ER -