NMR-Based Metabolomic Profiling for Brain Cancer Diagnosis and Treatment Guidance

Julia R. Zickus; José S. Enriquez; Paytience Smith; Bill T. Sun; Muxin Wang; Aldo Morales; Pratip K. Bhattacharya; Shivanand Pudakalakatti

doi:10.3390/metabo15090607

NMR-Based Metabolomic Profiling for Brain Cancer Diagnosis and Treatment Guidance

Julia R. Zickus
, José S. Enriquez
, Paytience Smith
, Bill T. Sun
, Muxin Wang
, Aldo Morales
, Pratip K. Bhattacharya
, Shivanand Pudakalakatti

Cancer Systems Imaging

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Nuclear magnetic resonance (NMR) spectroscopy is a routinely used analytical tool for studying chemical entities of varying molecular sizes, ranging from approximately 20 Da to ~45 kDa, and in some cases even larger. Over the past two decades, the use of NMR spectroscopy has significantly expanded to the study of metabolomics. In this medium-sized review, the application of NMR-based metabolomics in the diagnosis, therapeutic intervention, and guidance of therapy for various types of brain cancer is discussed.

Original language	English (US)
Article number	607
Journal	Metabolites
Volume	15
Issue number	9
DOIs	https://doi.org/10.3390/metabo15090607
State	Published - Sep 2025

Keywords

NMR spectroscopy
brain cancer
diagnosis
metabolomics
therapeutic intervention

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Molecular Biology

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10.3390/metabo15090607

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title = "NMR-Based Metabolomic Profiling for Brain Cancer Diagnosis and Treatment Guidance",

abstract = "Nuclear magnetic resonance (NMR) spectroscopy is a routinely used analytical tool for studying chemical entities of varying molecular sizes, ranging from approximately 20 Da to \textasciitilde{}45 kDa, and in some cases even larger. Over the past two decades, the use of NMR spectroscopy has significantly expanded to the study of metabolomics. In this medium-sized review, the application of NMR-based metabolomics in the diagnosis, therapeutic intervention, and guidance of therapy for various types of brain cancer is discussed.",

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language = "English (US)",

volume = "15",

journal = "Metabolites",

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T1 - NMR-Based Metabolomic Profiling for Brain Cancer Diagnosis and Treatment Guidance

AU - Zickus, Julia R.

AU - Enriquez, José S.

AU - Smith, Paytience

AU - Sun, Bill T.

AU - Wang, Muxin

AU - Morales, Aldo

AU - Bhattacharya, Pratip K.

AU - Pudakalakatti, Shivanand

PY - 2025/9

Y1 - 2025/9

N2 - Nuclear magnetic resonance (NMR) spectroscopy is a routinely used analytical tool for studying chemical entities of varying molecular sizes, ranging from approximately 20 Da to ~45 kDa, and in some cases even larger. Over the past two decades, the use of NMR spectroscopy has significantly expanded to the study of metabolomics. In this medium-sized review, the application of NMR-based metabolomics in the diagnosis, therapeutic intervention, and guidance of therapy for various types of brain cancer is discussed.

AB - Nuclear magnetic resonance (NMR) spectroscopy is a routinely used analytical tool for studying chemical entities of varying molecular sizes, ranging from approximately 20 Da to ~45 kDa, and in some cases even larger. Over the past two decades, the use of NMR spectroscopy has significantly expanded to the study of metabolomics. In this medium-sized review, the application of NMR-based metabolomics in the diagnosis, therapeutic intervention, and guidance of therapy for various types of brain cancer is discussed.

KW - NMR spectroscopy

KW - brain cancer

KW - diagnosis

KW - metabolomics

KW - therapeutic intervention

UR - https://www.scopus.com/pages/publications/105017420273

UR - https://www.scopus.com/pages/publications/105017420273#tab=citedBy

U2 - 10.3390/metabo15090607

DO - 10.3390/metabo15090607

M3 - Review article

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AN - SCOPUS:105017420273

SN - 2218-1989

VL - 15

JO - Metabolites

JF - Metabolites

IS - 9

M1 - 607

ER -

NMR-Based Metabolomic Profiling for Brain Cancer Diagnosis and Treatment Guidance

Abstract

Keywords

ASJC Scopus subject areas

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