Noisy silence: Non-coding RNA and heterochromatin formation at repetitive elements

Holger Bierhoff, Anna Postepska-Igielska, Ingrid Grummt

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

A significant fraction of eukaryotic genomes comprises repetitive sequences, including rRNA genes, centromeres, telomeres, and retrotransposons. Repetitive elements are hotspots for recombination and represent a serious challenge for genome integrity.maintaining these repeated elements in a compact heterochromatic structure suppresses recombination and unwanted mutagenic transposition, and is therefore indispensable for genomic stability.paradoxically, repetitive elements are not transcriptionally inert, but produce RNA that has important functions in regulating and reinforcing the heterochromatic state. Here, we review the role of non-coding RNA (ncRNA) in recruiting chromatin-modifying enzymes to repetitive genomic loci to establish a repressive chromatin structure that safeguards chromosome integrity and genome stability.

Original languageEnglish (US)
Pages (from-to)53-61
Number of pages9
JournalEpigenetics
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2014

Fingerprint

Untranslated RNA
Heterochromatin
Genomic Instability
Genetic Recombination
Chromatin
Genome
Retroelements
Chromosomal Instability
Centromere
Nucleic Acid Repetitive Sequences
Telomere
rRNA Genes
RNA
Enzymes

Keywords

  • Centromeres
  • Heterochromatin
  • Non-coding RNA
  • Repetitive elements
  • Retrotransposons
  • Telomeres
  • rDNA

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research

Cite this

Noisy silence : Non-coding RNA and heterochromatin formation at repetitive elements. / Bierhoff, Holger; Postepska-Igielska, Anna; Grummt, Ingrid.

In: Epigenetics, Vol. 9, No. 1, 01.01.2014, p. 53-61.

Research output: Contribution to journalReview article

Bierhoff, Holger ; Postepska-Igielska, Anna ; Grummt, Ingrid. / Noisy silence : Non-coding RNA and heterochromatin formation at repetitive elements. In: Epigenetics. 2014 ; Vol. 9, No. 1. pp. 53-61.
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