Non-chemokinetic neutrophil attractants derived from arachidonic acid

Stephen R. Turner; John A. Tanner

doi:10.1016/0309-1651(83)90188-1

Non-chemokinetic neutrophil attractants derived from arachidonic acid

Stephen R. Turner
, John A. Tanner

Research output: Contribution to journal › Article › peer-review

Abstract

Gradients of 15-hydroxy-5,8,11,13-eicosatetraenoic acid (15-HETE) and 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid (15-HPETE) were significantly and equally chemotactic for human neutrophils at 15-75μM. However, neither eicosanoid stimulated random migration when presented isotropically to cells, indicating a total lack of chemokinetic activity. These unique non-chemokinetic chemoattractants may be useful tools for dissecting the chemokinetic phase of neutrophil activation from the chemotactic phase.

Original language	English (US)
Pages (from-to)	843-848
Number of pages	6
Journal	Cell Biology International Reports
Volume	7
Issue number	10
DOIs	https://doi.org/10.1016/0309-1651(83)90188-1
State	Published - Oct 1983
Externally published	Yes

ASJC Scopus subject areas

Cell Biology

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10.1016/0309-1651(83)90188-1

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@article{fa016c0805274ea29c17ed7117772414,

title = "Non-chemokinetic neutrophil attractants derived from arachidonic acid",

abstract = "Gradients of 15-hydroxy-5,8,11,13-eicosatetraenoic acid (15-HETE) and 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid (15-HPETE) were significantly and equally chemotactic for human neutrophils at 15-75μM. However, neither eicosanoid stimulated random migration when presented isotropically to cells, indicating a total lack of chemokinetic activity. These unique non-chemokinetic chemoattractants may be useful tools for dissecting the chemokinetic phase of neutrophil activation from the chemotactic phase.",

author = "Turner, \{Stephen R.\} and Tanner, \{John A.\}",

note = "Funding Information: We thank Ms. Laurie McCosh for expert technical assistance and Dr. Joan Bursey for mass spectral analyses. Supported by Research Grant CA 23681 awarded by the National Institutes of Health, DHEW.",

year = "1983",

month = oct,

doi = "10.1016/0309-1651(83)90188-1",

language = "English (US)",

volume = "7",

pages = "843--848",

journal = "Cell Biology International Reports",

issn = "0309-1651",

publisher = "Academic Press Inc.",

number = "10",

}

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T1 - Non-chemokinetic neutrophil attractants derived from arachidonic acid

AU - Turner, Stephen R.

AU - Tanner, John A.

N1 - Funding Information: We thank Ms. Laurie McCosh for expert technical assistance and Dr. Joan Bursey for mass spectral analyses. Supported by Research Grant CA 23681 awarded by the National Institutes of Health, DHEW.

PY - 1983/10

Y1 - 1983/10

N2 - Gradients of 15-hydroxy-5,8,11,13-eicosatetraenoic acid (15-HETE) and 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid (15-HPETE) were significantly and equally chemotactic for human neutrophils at 15-75μM. However, neither eicosanoid stimulated random migration when presented isotropically to cells, indicating a total lack of chemokinetic activity. These unique non-chemokinetic chemoattractants may be useful tools for dissecting the chemokinetic phase of neutrophil activation from the chemotactic phase.

AB - Gradients of 15-hydroxy-5,8,11,13-eicosatetraenoic acid (15-HETE) and 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid (15-HPETE) were significantly and equally chemotactic for human neutrophils at 15-75μM. However, neither eicosanoid stimulated random migration when presented isotropically to cells, indicating a total lack of chemokinetic activity. These unique non-chemokinetic chemoattractants may be useful tools for dissecting the chemokinetic phase of neutrophil activation from the chemotactic phase.

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DO - 10.1016/0309-1651(83)90188-1

M3 - Article

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AN - SCOPUS:0021044560

SN - 0309-1651

VL - 7

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EP - 848

JO - Cell Biology International Reports

JF - Cell Biology International Reports

IS - 10

ER -

Non-chemokinetic neutrophil attractants derived from arachidonic acid

Abstract

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