Abstract
Infectious diarrhea is a common occurrence in the immunosuppressed population. We present a 43-year-old individual with large-volume stool output Norovirus acute gastroenteritis in the setting of relapsed refractory acute myelogenous leukemia, hematopoietic stem cell transplantation, and biopsy-proven cutaneous and pulmonary graft-versus-host disease. Therapeutic options such as intravenous immunoglobulin or reduction of immunosuppressants were not a feasible choice. A prompt clinical cure was achieved with nitazoxanide, a broad-spectrum antimicrobial agent. Nitazoxanide may be a safe therapeutic alternative, in which a reduction in immunosuppression may not be a viable option.
Original language | English (US) |
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Pages (from-to) | 394-397 |
Number of pages | 4 |
Journal | Journal of Infection |
Volume | 63 |
Issue number | 5 |
DOIs | |
State | Published - Nov 2011 |
Keywords
- Gastroenteritis
- Graft-versus-host
- Hematopoietic stem cell transplant
- Immunosuppression
- Leukemia
- Nitazoxanide
- Norovirus
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases