TY - JOUR
T1 - Novel Mutations Involving NF-κB and B-Cell Signaling Pathways in Primary Cutaneous Large B-Cell Lymphoma, Leg-Type and Comparison with Sézary Syndrome
AU - Kim, Esther J.
AU - Lewis, Daniel J.
AU - Duvic, Madeleine
N1 - Publisher Copyright:
© 2017 The Authors
PY - 2017/9
Y1 - 2017/9
N2 - Multiple genomic mutations, especially those involving the NF-κB pathway, have been characterized in primary cutaneous large B-cell lymphoma, leg type. However, its genomic profiling remains limited given its rarity. In a recent study, Mareschal et al. performed next-generation sequencing and whole-exome sequencing, identifying new driver genes while also confirming the role of myeloid differentiation primary response gene 88 in the molecular pathogenesis of the disease.
AB - Multiple genomic mutations, especially those involving the NF-κB pathway, have been characterized in primary cutaneous large B-cell lymphoma, leg type. However, its genomic profiling remains limited given its rarity. In a recent study, Mareschal et al. performed next-generation sequencing and whole-exome sequencing, identifying new driver genes while also confirming the role of myeloid differentiation primary response gene 88 in the molecular pathogenesis of the disease.
UR - http://www.scopus.com/inward/record.url?scp=85028362217&partnerID=8YFLogxK
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U2 - 10.1016/j.jid.2017.06.013
DO - 10.1016/j.jid.2017.06.013
M3 - Comment/debate
C2 - 28843295
AN - SCOPUS:85028362217
SN - 0022-202X
VL - 137
SP - 1831
EP - 1833
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 9
ER -