Novel Radiotherapy Technologies in the Treatment of Gastrointestinal Malignancies

Shraddha Mahesh Dalwadi, Joseph M. Herman, Prajnan Das, Emma B. Holliday

Research output: Contribution to journalReview article

Abstract

Over the past 2 decades, major technical advances in radiation therapy planning and delivery have made it possible to deliver higher doses to select high-risk volumes. This has helped to expand the role of radiation therapy in the treatment of gastrointestinal malignancies. Whereas dose escalation was previously limited by the radiosensitivity of normal tissues within and adjacent to the gastrointestinal tract, advances in target delineation, patient immobilization, treatment planning, and image-guided treatment delivery have greatly improved the therapeutic ratio. More conformal radiation modalities can offer further dose optimization to target volumes while sparing normal tissue from toxicity.

Original languageEnglish (US)
Pages (from-to)29-43
Number of pages15
JournalHematology/Oncology Clinics of North America
Volume34
Issue number1
DOIs
StatePublished - Feb 2020

Fingerprint

Proton Therapy
Radiotherapy
Technology
Neoplasms
Radiation Tolerance
Therapeutics
Immobilization
Gastrointestinal Tract
Radiation

Keywords

  • Image guidance
  • Proton therapy
  • Radiotherapy
  • SBRT

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

Novel Radiotherapy Technologies in the Treatment of Gastrointestinal Malignancies. / Dalwadi, Shraddha Mahesh; Herman, Joseph M.; Das, Prajnan; Holliday, Emma B.

In: Hematology/Oncology Clinics of North America, Vol. 34, No. 1, 02.2020, p. 29-43.

Research output: Contribution to journalReview article

@article{086ea6c747144dea9f1ce876e392f67a,
title = "Novel Radiotherapy Technologies in the Treatment of Gastrointestinal Malignancies",
abstract = "Over the past 2 decades, major technical advances in radiation therapy planning and delivery have made it possible to deliver higher doses to select high-risk volumes. This has helped to expand the role of radiation therapy in the treatment of gastrointestinal malignancies. Whereas dose escalation was previously limited by the radiosensitivity of normal tissues within and adjacent to the gastrointestinal tract, advances in target delineation, patient immobilization, treatment planning, and image-guided treatment delivery have greatly improved the therapeutic ratio. More conformal radiation modalities can offer further dose optimization to target volumes while sparing normal tissue from toxicity.",
keywords = "Image guidance, Proton therapy, Radiotherapy, SBRT",
author = "Dalwadi, {Shraddha Mahesh} and Herman, {Joseph M.} and Prajnan Das and Holliday, {Emma B.}",
year = "2020",
month = "2",
doi = "10.1016/j.hoc.2019.08.016",
language = "English (US)",
volume = "34",
pages = "29--43",
journal = "Hematology/Oncology Clinics of North America",
issn = "0889-8588",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Novel Radiotherapy Technologies in the Treatment of Gastrointestinal Malignancies

AU - Dalwadi, Shraddha Mahesh

AU - Herman, Joseph M.

AU - Das, Prajnan

AU - Holliday, Emma B.

PY - 2020/2

Y1 - 2020/2

N2 - Over the past 2 decades, major technical advances in radiation therapy planning and delivery have made it possible to deliver higher doses to select high-risk volumes. This has helped to expand the role of radiation therapy in the treatment of gastrointestinal malignancies. Whereas dose escalation was previously limited by the radiosensitivity of normal tissues within and adjacent to the gastrointestinal tract, advances in target delineation, patient immobilization, treatment planning, and image-guided treatment delivery have greatly improved the therapeutic ratio. More conformal radiation modalities can offer further dose optimization to target volumes while sparing normal tissue from toxicity.

AB - Over the past 2 decades, major technical advances in radiation therapy planning and delivery have made it possible to deliver higher doses to select high-risk volumes. This has helped to expand the role of radiation therapy in the treatment of gastrointestinal malignancies. Whereas dose escalation was previously limited by the radiosensitivity of normal tissues within and adjacent to the gastrointestinal tract, advances in target delineation, patient immobilization, treatment planning, and image-guided treatment delivery have greatly improved the therapeutic ratio. More conformal radiation modalities can offer further dose optimization to target volumes while sparing normal tissue from toxicity.

KW - Image guidance

KW - Proton therapy

KW - Radiotherapy

KW - SBRT

UR - http://www.scopus.com/inward/record.url?scp=85074460746&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074460746&partnerID=8YFLogxK

U2 - 10.1016/j.hoc.2019.08.016

DO - 10.1016/j.hoc.2019.08.016

M3 - Review article

C2 - 31739949

AN - SCOPUS:85074460746

VL - 34

SP - 29

EP - 43

JO - Hematology/Oncology Clinics of North America

JF - Hematology/Oncology Clinics of North America

SN - 0889-8588

IS - 1

ER -