TY - JOUR
T1 - Novel translocation in acute megakaryoblastic leukemia (AML-M7)
AU - Toretsky, Jeffrey A.
AU - Everly, Eileen M.
AU - Padilla-Nash, Hesed M.
AU - Chen, Allen
AU - Abruzzo, Lynne V.
AU - Eskenazi, Allen E.
AU - Frantz, Chris
AU - Ried, Thomas
AU - Stamberg, Judith
PY - 2003/5
Y1 - 2003/5
N2 - The authors report a unique translocation in a patient with M7 acute myeloid leukemia and review the literature. A 22-month-old girl without Down syndrome was diagnosed with acute myeloid leukemia, subtype M7 (AML-M7), and died with relapsed disease following bone marrow transplantation. Tumor cells were evaluated using cytogenetics (including spectral karyotyping), immunohistochemistry, and flow cytometry. The patient was found to have a previously unreported complex translocation as follows: 50,XX,der(1)t(1;5)(p36?.1;p15?.1),del(5)(p15?.1), +6,+der(6;7)(?;?),der(7)t(6;7)(?;p22)[2],der(9)t(6;9) (?;p21)t(9;14)(q34;q11.2-q13),+10,t(12;16)(p13;q24),-14[2], del(14)(q13)[2],+der(19)t(1;19)(?;p13.3),+22[cp 4]. AML-M7 in non-Down syndrome patients is a rare disease that requires improved prognostic markers.
AB - The authors report a unique translocation in a patient with M7 acute myeloid leukemia and review the literature. A 22-month-old girl without Down syndrome was diagnosed with acute myeloid leukemia, subtype M7 (AML-M7), and died with relapsed disease following bone marrow transplantation. Tumor cells were evaluated using cytogenetics (including spectral karyotyping), immunohistochemistry, and flow cytometry. The patient was found to have a previously unreported complex translocation as follows: 50,XX,der(1)t(1;5)(p36?.1;p15?.1),del(5)(p15?.1), +6,+der(6;7)(?;?),der(7)t(6;7)(?;p22)[2],der(9)t(6;9) (?;p21)t(9;14)(q34;q11.2-q13),+10,t(12;16)(p13;q24),-14[2], del(14)(q13)[2],+der(19)t(1;19)(?;p13.3),+22[cp 4]. AML-M7 in non-Down syndrome patients is a rare disease that requires improved prognostic markers.
KW - Acute myeloid leukemia
KW - Cytogenetics
KW - Megakaryocytic leukemia
KW - Spectral karyotyping
KW - Translocation
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U2 - 10.1097/00043426-200305000-00009
DO - 10.1097/00043426-200305000-00009
M3 - Article
C2 - 12759627
AN - SCOPUS:0038221258
SN - 1077-4114
VL - 25
SP - 396
EP - 402
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
IS - 5
ER -