Novel translocation in acute megakaryoblastic leukemia (AML-M7)

Jeffrey A. Toretsky, Eileen M. Everly, Hesed M. Padilla-Nash, Allen Chen, Lynne V. Abruzzo, Allen E. Eskenazi, Chris Frantz, Thomas Ried, Judith Stamberg

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The authors report a unique translocation in a patient with M7 acute myeloid leukemia and review the literature. A 22-month-old girl without Down syndrome was diagnosed with acute myeloid leukemia, subtype M7 (AML-M7), and died with relapsed disease following bone marrow transplantation. Tumor cells were evaluated using cytogenetics (including spectral karyotyping), immunohistochemistry, and flow cytometry. The patient was found to have a previously unreported complex translocation as follows: 50,XX,der(1)t(1;5)(p36?.1;p15?.1),del(5)(p15?.1), +6,+der(6;7)(?;?),der(7)t(6;7)(?;p22)[2],der(9)t(6;9) (?;p21)t(9;14)(q34;q11.2-q13),+10,t(12;16)(p13;q24),-14[2], del(14)(q13)[2],+der(19)t(1;19)(?;p13.3),+22[cp 4]. AML-M7 in non-Down syndrome patients is a rare disease that requires improved prognostic markers.

Original languageEnglish (US)
Pages (from-to)396-402
Number of pages7
JournalJournal of Pediatric Hematology/Oncology
Volume25
Issue number5
DOIs
StatePublished - May 2003

Keywords

  • Acute myeloid leukemia
  • Cytogenetics
  • Megakaryocytic leukemia
  • Spectral karyotyping
  • Translocation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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