Novel translocation in acute megakaryoblastic leukemia (AML-M7)

Jeffrey A. Toretsky, Eileen M. Everly, Hesed M. Padilla-Nash, Allen Chen, Lynne Abruzzo, Allen E. Eskenazi, Chris Frantz, Thomas Ried, Judith Stamberg

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The authors report a unique translocation in a patient with M7 acute myeloid leukemia and review the literature. A 22-month-old girl without Down syndrome was diagnosed with acute myeloid leukemia, subtype M7 (AML-M7), and died with relapsed disease following bone marrow transplantation. Tumor cells were evaluated using cytogenetics (including spectral karyotyping), immunohistochemistry, and flow cytometry. The patient was found to have a previously unreported complex translocation as follows: 50,XX,der(1)t(1;5)(p36?.1;p15?.1),del(5)(p15?.1), +6,+der(6;7)(?;?),der(7)t(6;7)(?;p22)[2],der(9)t(6;9) (?;p21)t(9;14)(q34;q11.2-q13),+10,t(12;16)(p13;q24),-14[2], del(14)(q13)[2],+der(19)t(1;19)(?;p13.3),+22[cp 4]. AML-M7 in non-Down syndrome patients is a rare disease that requires improved prognostic markers.

Original languageEnglish (US)
Pages (from-to)396-402
Number of pages7
JournalJournal of Pediatric Hematology/Oncology
Volume25
Issue number5
DOIs
StatePublished - May 1 2003

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Leukemia, Megakaryoblastic, Acute
Spectral Karyotyping
Rare Diseases
Down Syndrome
Bone Marrow Transplantation
Cytogenetics
Flow Cytometry
Immunohistochemistry
Neoplasms

Keywords

  • Acute myeloid leukemia
  • Cytogenetics
  • Megakaryocytic leukemia
  • Spectral karyotyping
  • Translocation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Toretsky, J. A., Everly, E. M., Padilla-Nash, H. M., Chen, A., Abruzzo, L., Eskenazi, A. E., ... Stamberg, J. (2003). Novel translocation in acute megakaryoblastic leukemia (AML-M7). Journal of Pediatric Hematology/Oncology, 25(5), 396-402. https://doi.org/10.1097/00043426-200305000-00009

Novel translocation in acute megakaryoblastic leukemia (AML-M7). / Toretsky, Jeffrey A.; Everly, Eileen M.; Padilla-Nash, Hesed M.; Chen, Allen; Abruzzo, Lynne; Eskenazi, Allen E.; Frantz, Chris; Ried, Thomas; Stamberg, Judith.

In: Journal of Pediatric Hematology/Oncology, Vol. 25, No. 5, 01.05.2003, p. 396-402.

Research output: Contribution to journalArticle

Toretsky, JA, Everly, EM, Padilla-Nash, HM, Chen, A, Abruzzo, L, Eskenazi, AE, Frantz, C, Ried, T & Stamberg, J 2003, 'Novel translocation in acute megakaryoblastic leukemia (AML-M7)', Journal of Pediatric Hematology/Oncology, vol. 25, no. 5, pp. 396-402. https://doi.org/10.1097/00043426-200305000-00009
Toretsky JA, Everly EM, Padilla-Nash HM, Chen A, Abruzzo L, Eskenazi AE et al. Novel translocation in acute megakaryoblastic leukemia (AML-M7). Journal of Pediatric Hematology/Oncology. 2003 May 1;25(5):396-402. https://doi.org/10.1097/00043426-200305000-00009
Toretsky, Jeffrey A. ; Everly, Eileen M. ; Padilla-Nash, Hesed M. ; Chen, Allen ; Abruzzo, Lynne ; Eskenazi, Allen E. ; Frantz, Chris ; Ried, Thomas ; Stamberg, Judith. / Novel translocation in acute megakaryoblastic leukemia (AML-M7). In: Journal of Pediatric Hematology/Oncology. 2003 ; Vol. 25, No. 5. pp. 396-402.
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