Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human breast carcinoma

Hisashi Saji, Masakazu Toi, Shigehira Saji, Morio Koike, Kimitoshi Kohno, Michihiko Kuwano

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Drug resistance is a common clinical problem in cancer treatment. The overexpression of P-glycoprotein appears to be closely associated with multi-drug resistance to anticancer agents. YB-1 binds to the Y-box in the promoter region of MDR1, which encodes P-glycoprotein. We evaluated the correlation between nuclear YB-1 and P-glycoprotein expression and other molecules, such as hormonal receptors, angiogenic factors, immune factors, and methalloprotease in 63 human breast cancers. Nuclear YB-1 expression had a significant correlation with P-glycoprotein and PgR expression, and also with CD68 grade, concerning accumulation of tumor associated macrophages. This series did not demonstrate P-glycoprotein and nuclear YB-1 expression might be one of the useful prognostic marker of breast cancer.

Original languageEnglish (US)
Pages (from-to)191-197
Number of pages7
JournalCancer Letters
Volume190
Issue number2
DOIs
StatePublished - Feb 20 2003

Fingerprint

P-Glycoprotein
Breast Neoplasms
Proteins
Angiogenesis Inducing Agents
Immunologic Factors
Multiple Drug Resistance
Drug Resistance
Genetic Promoter Regions
Antineoplastic Agents
Neoplasms
Macrophages

Keywords

  • Breast carcinoma
  • Estrogen receptor
  • Multi-drug resistance
  • P-glycoprotein
  • PgR
  • YB-1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human breast carcinoma. / Saji, Hisashi; Toi, Masakazu; Saji, Shigehira; Koike, Morio; Kohno, Kimitoshi; Kuwano, Michihiko.

In: Cancer Letters, Vol. 190, No. 2, 20.02.2003, p. 191-197.

Research output: Contribution to journalArticle

Saji, Hisashi ; Toi, Masakazu ; Saji, Shigehira ; Koike, Morio ; Kohno, Kimitoshi ; Kuwano, Michihiko. / Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human breast carcinoma. In: Cancer Letters. 2003 ; Vol. 190, No. 2. pp. 191-197.
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