Nucleic Acid Delivery for Endothelial Dysfunction in Cardiovascular Diseases

Dipti Deshpande; David R. Janero; Victor Segura-Ibarra; Elvin Blanco; Mansoor M. Amiji

doi:10.14797/mdcj-12-3-134

Nucleic Acid Delivery for Endothelial Dysfunction in Cardiovascular Diseases

Dipti Deshpande, David R. Janero, Victor Segura-Ibarra, Elvin Blanco, Mansoor M. Amiji

Molecular & Cellular Oncology

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Endothelial dysfunction has been implicated in the pathophysiology of multiple cardiovascular diseases and involves components of both innate and acquired immune mechanisms. Identifying signature patterns and targets associated with endothelial dysfunction can help in the development of novel nanotherapeutic platforms for treatment of vascular diseases. This review discusses nucleic acid-based regulation of endothelial function and the different nucleic acid-based nanotherapeutic approaches designed to target endothelial dysfunction in cardiovascular disorders.

Original language	English (US)
Pages (from-to)	134-140
Number of pages	7
Journal	Methodist DeBakey cardiovascular journal
Volume	12
Issue number	3
DOIs	https://doi.org/10.14797/mdcj-12-3-134
State	Published - Sep 1 2016

Keywords

CVD
DNA damage
cardiovascular diseases
endothelium
inflammation
miRNA
nanoparticle delivery
nucleic acids
oligonucleotide-based therapeutics
oxidative stress

ASJC Scopus subject areas

General Medicine

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title = "Nucleic Acid Delivery for Endothelial Dysfunction in Cardiovascular Diseases",

abstract = "Endothelial dysfunction has been implicated in the pathophysiology of multiple cardiovascular diseases and involves components of both innate and acquired immune mechanisms. Identifying signature patterns and targets associated with endothelial dysfunction can help in the development of novel nanotherapeutic platforms for treatment of vascular diseases. This review discusses nucleic acid-based regulation of endothelial function and the different nucleic acid-based nanotherapeutic approaches designed to target endothelial dysfunction in cardiovascular disorders.",

keywords = "CVD, DNA damage, cardiovascular diseases, endothelium, inflammation, miRNA, nanoparticle delivery, nucleic acids, oligonucleotide-based therapeutics, oxidative stress",

author = "Dipti Deshpande and Janero, {David R.} and Victor Segura-Ibarra and Elvin Blanco and Amiji, {Mansoor M.}",

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AU - Janero, David R.

AU - Segura-Ibarra, Victor

AU - Blanco, Elvin

AU - Amiji, Mansoor M.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Endothelial dysfunction has been implicated in the pathophysiology of multiple cardiovascular diseases and involves components of both innate and acquired immune mechanisms. Identifying signature patterns and targets associated with endothelial dysfunction can help in the development of novel nanotherapeutic platforms for treatment of vascular diseases. This review discusses nucleic acid-based regulation of endothelial function and the different nucleic acid-based nanotherapeutic approaches designed to target endothelial dysfunction in cardiovascular disorders.

AB - Endothelial dysfunction has been implicated in the pathophysiology of multiple cardiovascular diseases and involves components of both innate and acquired immune mechanisms. Identifying signature patterns and targets associated with endothelial dysfunction can help in the development of novel nanotherapeutic platforms for treatment of vascular diseases. This review discusses nucleic acid-based regulation of endothelial function and the different nucleic acid-based nanotherapeutic approaches designed to target endothelial dysfunction in cardiovascular disorders.

KW - CVD

KW - DNA damage

KW - cardiovascular diseases

KW - endothelium

KW - inflammation

KW - miRNA

KW - nanoparticle delivery

KW - nucleic acids

KW - oligonucleotide-based therapeutics

KW - oxidative stress

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AN - SCOPUS:85020374653

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JO - Methodist DeBakey cardiovascular journal

JF - Methodist DeBakey cardiovascular journal

IS - 3

ER -

Nucleic Acid Delivery for Endothelial Dysfunction in Cardiovascular Diseases

Abstract

Keywords

ASJC Scopus subject areas

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