O blood type is associated with unfavorable distant-metastasis-free survival in female patients with nasopharyngeal carcinoma: A retrospective study of 2439 patients from epidemic area

Guan Nan Wang, Shu Zhou, Chen Chen, Hui Chang, Yalan Tao, Shan Liu, Xiao Hui Wang, Wen Wen Zhang, Yang Liu, Song Ran Liu, Shi Rong Ding, Xin Yang, Zheng Qian Ye, Yi Feng Gao, Yun Fei Xia

Research output: Contribution to journalArticle

Abstract

Purpose: To identify the association between ABO blood type and the survivals in nasopharyngeal carcinoma patients. Patients and methods: We retrospectively analyzed 2439 consecutive non-metastasis nasopharyngeal carcinoma patients between January 2001 and December 2004 at the Sun Yat-sen University Cancer Center. Survival outcomes were compared using Kaplan-Meier method. Univariate and multivariate analysis was performed by Cox regression model. Chi-square test was performed to compare categorical variables. Results: In the whole patients, compared with non-O blood type (A, B, and AB) patients, O blood type patients had significantly lower 5-year distant metastasis-free survival (DMFS) (adjusted hazard ratio (aHR)= 1.268, 95% CI 1.010-1.592, P=0.041). Moreover, we observed in female patients, O blood type patients had significantly lower 5-year overall survival (OS), disease-specific survival (DSS) and DMFS than those with non-O blood type (aHR=1.495, 95% CI 1.032-2.165, P=0.034 for OS; aHR=1.566, 95% CI 1.054-2.328, P=0.026 for DSS; aHR=1.779, 95% CI 1.056-2.998, P=0.030 for DMFS). In male patients, there was no significant difference observed between O blood type patients and non-O blood type patients in any survival endpoints. Conclusion: O blood type was associated with an unfavorable DMFS in female patients with nasopharyngeal carcinoma in epidemic area, which might contribute to unfavorable OS and DSS in female patients, even contribute to a lower DMFS in the whole patients. It might be beneficial to predict metastasis so as to guide the treatment in female patients with nasopharyngeal carcinoma in epidemic area.

Original languageEnglish (US)
Pages (from-to)1297-1306
Number of pages10
JournalJournal of Cancer
Volume10
Issue number5
DOIs
StatePublished - Jan 1 2019

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Retrospective Studies
Neoplasm Metastasis
Survival
Nasopharyngeal carcinoma
Solar System
Chi-Square Distribution
Proportional Hazards Models
Multivariate Analysis

Keywords

  • Blood type
  • Distant-metastasis-free survival
  • Female patients
  • Nasopharyngeal carcinoma

ASJC Scopus subject areas

  • Oncology

Cite this

O blood type is associated with unfavorable distant-metastasis-free survival in female patients with nasopharyngeal carcinoma : A retrospective study of 2439 patients from epidemic area. / Wang, Guan Nan; Zhou, Shu; Chen, Chen; Chang, Hui; Tao, Yalan; Liu, Shan; Wang, Xiao Hui; Zhang, Wen Wen; Liu, Yang; Liu, Song Ran; Ding, Shi Rong; Yang, Xin; Ye, Zheng Qian; Gao, Yi Feng; Xia, Yun Fei.

In: Journal of Cancer, Vol. 10, No. 5, 01.01.2019, p. 1297-1306.

Research output: Contribution to journalArticle

Wang, GN, Zhou, S, Chen, C, Chang, H, Tao, Y, Liu, S, Wang, XH, Zhang, WW, Liu, Y, Liu, SR, Ding, SR, Yang, X, Ye, ZQ, Gao, YF & Xia, YF 2019, 'O blood type is associated with unfavorable distant-metastasis-free survival in female patients with nasopharyngeal carcinoma: A retrospective study of 2439 patients from epidemic area', Journal of Cancer, vol. 10, no. 5, pp. 1297-1306. https://doi.org/10.7150/jca.28372
Wang, Guan Nan ; Zhou, Shu ; Chen, Chen ; Chang, Hui ; Tao, Yalan ; Liu, Shan ; Wang, Xiao Hui ; Zhang, Wen Wen ; Liu, Yang ; Liu, Song Ran ; Ding, Shi Rong ; Yang, Xin ; Ye, Zheng Qian ; Gao, Yi Feng ; Xia, Yun Fei. / O blood type is associated with unfavorable distant-metastasis-free survival in female patients with nasopharyngeal carcinoma : A retrospective study of 2439 patients from epidemic area. In: Journal of Cancer. 2019 ; Vol. 10, No. 5. pp. 1297-1306.
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abstract = "Purpose: To identify the association between ABO blood type and the survivals in nasopharyngeal carcinoma patients. Patients and methods: We retrospectively analyzed 2439 consecutive non-metastasis nasopharyngeal carcinoma patients between January 2001 and December 2004 at the Sun Yat-sen University Cancer Center. Survival outcomes were compared using Kaplan-Meier method. Univariate and multivariate analysis was performed by Cox regression model. Chi-square test was performed to compare categorical variables. Results: In the whole patients, compared with non-O blood type (A, B, and AB) patients, O blood type patients had significantly lower 5-year distant metastasis-free survival (DMFS) (adjusted hazard ratio (aHR)= 1.268, 95{\%} CI 1.010-1.592, P=0.041). Moreover, we observed in female patients, O blood type patients had significantly lower 5-year overall survival (OS), disease-specific survival (DSS) and DMFS than those with non-O blood type (aHR=1.495, 95{\%} CI 1.032-2.165, P=0.034 for OS; aHR=1.566, 95{\%} CI 1.054-2.328, P=0.026 for DSS; aHR=1.779, 95{\%} CI 1.056-2.998, P=0.030 for DMFS). In male patients, there was no significant difference observed between O blood type patients and non-O blood type patients in any survival endpoints. Conclusion: O blood type was associated with an unfavorable DMFS in female patients with nasopharyngeal carcinoma in epidemic area, which might contribute to unfavorable OS and DSS in female patients, even contribute to a lower DMFS in the whole patients. It might be beneficial to predict metastasis so as to guide the treatment in female patients with nasopharyngeal carcinoma in epidemic area.",
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author = "Wang, {Guan Nan} and Shu Zhou and Chen Chen and Hui Chang and Yalan Tao and Shan Liu and Wang, {Xiao Hui} and Zhang, {Wen Wen} and Yang Liu and Liu, {Song Ran} and Ding, {Shi Rong} and Xin Yang and Ye, {Zheng Qian} and Gao, {Yi Feng} and Xia, {Yun Fei}",
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T1 - O blood type is associated with unfavorable distant-metastasis-free survival in female patients with nasopharyngeal carcinoma

T2 - A retrospective study of 2439 patients from epidemic area

AU - Wang, Guan Nan

AU - Zhou, Shu

AU - Chen, Chen

AU - Chang, Hui

AU - Tao, Yalan

AU - Liu, Shan

AU - Wang, Xiao Hui

AU - Zhang, Wen Wen

AU - Liu, Yang

AU - Liu, Song Ran

AU - Ding, Shi Rong

AU - Yang, Xin

AU - Ye, Zheng Qian

AU - Gao, Yi Feng

AU - Xia, Yun Fei

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: To identify the association between ABO blood type and the survivals in nasopharyngeal carcinoma patients. Patients and methods: We retrospectively analyzed 2439 consecutive non-metastasis nasopharyngeal carcinoma patients between January 2001 and December 2004 at the Sun Yat-sen University Cancer Center. Survival outcomes were compared using Kaplan-Meier method. Univariate and multivariate analysis was performed by Cox regression model. Chi-square test was performed to compare categorical variables. Results: In the whole patients, compared with non-O blood type (A, B, and AB) patients, O blood type patients had significantly lower 5-year distant metastasis-free survival (DMFS) (adjusted hazard ratio (aHR)= 1.268, 95% CI 1.010-1.592, P=0.041). Moreover, we observed in female patients, O blood type patients had significantly lower 5-year overall survival (OS), disease-specific survival (DSS) and DMFS than those with non-O blood type (aHR=1.495, 95% CI 1.032-2.165, P=0.034 for OS; aHR=1.566, 95% CI 1.054-2.328, P=0.026 for DSS; aHR=1.779, 95% CI 1.056-2.998, P=0.030 for DMFS). In male patients, there was no significant difference observed between O blood type patients and non-O blood type patients in any survival endpoints. Conclusion: O blood type was associated with an unfavorable DMFS in female patients with nasopharyngeal carcinoma in epidemic area, which might contribute to unfavorable OS and DSS in female patients, even contribute to a lower DMFS in the whole patients. It might be beneficial to predict metastasis so as to guide the treatment in female patients with nasopharyngeal carcinoma in epidemic area.

AB - Purpose: To identify the association between ABO blood type and the survivals in nasopharyngeal carcinoma patients. Patients and methods: We retrospectively analyzed 2439 consecutive non-metastasis nasopharyngeal carcinoma patients between January 2001 and December 2004 at the Sun Yat-sen University Cancer Center. Survival outcomes were compared using Kaplan-Meier method. Univariate and multivariate analysis was performed by Cox regression model. Chi-square test was performed to compare categorical variables. Results: In the whole patients, compared with non-O blood type (A, B, and AB) patients, O blood type patients had significantly lower 5-year distant metastasis-free survival (DMFS) (adjusted hazard ratio (aHR)= 1.268, 95% CI 1.010-1.592, P=0.041). Moreover, we observed in female patients, O blood type patients had significantly lower 5-year overall survival (OS), disease-specific survival (DSS) and DMFS than those with non-O blood type (aHR=1.495, 95% CI 1.032-2.165, P=0.034 for OS; aHR=1.566, 95% CI 1.054-2.328, P=0.026 for DSS; aHR=1.779, 95% CI 1.056-2.998, P=0.030 for DMFS). In male patients, there was no significant difference observed between O blood type patients and non-O blood type patients in any survival endpoints. Conclusion: O blood type was associated with an unfavorable DMFS in female patients with nasopharyngeal carcinoma in epidemic area, which might contribute to unfavorable OS and DSS in female patients, even contribute to a lower DMFS in the whole patients. It might be beneficial to predict metastasis so as to guide the treatment in female patients with nasopharyngeal carcinoma in epidemic area.

KW - Blood type

KW - Distant-metastasis-free survival

KW - Female patients

KW - Nasopharyngeal carcinoma

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