TY - JOUR
T1 - Obesity and Cardiovascular Disease
T2 - a Risk Factor or a Risk Marker?
AU - Mandviwala, Taher
AU - Khalid, Umair
AU - Deswal, Anita
N1 - Funding Information:
Anita Deswal declares research support from Novartis as site-PI of multicenter clinical trial, and grant support from the NIH as site-PI for clinical trials.
Publisher Copyright:
© 2016, Springer Science+Business Media New York (outside the USA).
PY - 2016/5/1
Y1 - 2016/5/1
N2 - In the USA, 69 % of adults are either overweight or obese and 35 % are obese. Obesity is associated with an increased incidence of various cardiovascular disorders. Obesity is a risk marker for cardiovascular disease, in that it is associated with a much higher prevalence of comorbidities such as diabetes, hypertension, and metabolic syndrome, which then increase the risk for cardiovascular disease. However, in addition, obesity may also be an independent risk factor for the development of cardiovascular disease. Furthermore, although obesity has been shown to be an independent risk factor for several cardiovascular diseases, it is often associated with improved survival once the diagnosis of the cardiovascular disease has been made, leading to the term “obesity paradox.” Several pathways linking obesity and cardiovascular disease have been described. In this review, we attempt to summarize the complex relationship between obesity and cardiovascular disorders, in particular coronary atherosclerosis, heart failure, and atrial fibrillation.
AB - In the USA, 69 % of adults are either overweight or obese and 35 % are obese. Obesity is associated with an increased incidence of various cardiovascular disorders. Obesity is a risk marker for cardiovascular disease, in that it is associated with a much higher prevalence of comorbidities such as diabetes, hypertension, and metabolic syndrome, which then increase the risk for cardiovascular disease. However, in addition, obesity may also be an independent risk factor for the development of cardiovascular disease. Furthermore, although obesity has been shown to be an independent risk factor for several cardiovascular diseases, it is often associated with improved survival once the diagnosis of the cardiovascular disease has been made, leading to the term “obesity paradox.” Several pathways linking obesity and cardiovascular disease have been described. In this review, we attempt to summarize the complex relationship between obesity and cardiovascular disorders, in particular coronary atherosclerosis, heart failure, and atrial fibrillation.
KW - Atherosclerosis
KW - Cardiovascular disease
KW - Coronary artery disease
KW - Heart failure
KW - Hypertension
KW - Obesity
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U2 - 10.1007/s11883-016-0575-4
DO - 10.1007/s11883-016-0575-4
M3 - Review article
C2 - 26973130
AN - SCOPUS:84960959031
SN - 1523-3804
VL - 18
JO - Current atherosclerosis reports
JF - Current atherosclerosis reports
IS - 5
M1 - 21
ER -